ArticleNature2021
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 375 papers.
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375citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
375 citing papers in PubMed.
- Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission.Nature communications · 2024Trial
- Baseline Serum and Stool Microbiome Biomarkers Predict Clinical Efficacy and Tissue Molecular Response After Ritlecitinib Induction Therapy in Ulcerative Colitis.Journal of Crohn's & colitis · 2024Trial
- The role of gut microbiome in aging-associated diseases: where do we stand now and how technology will transform the future.Gut microbes · 2026Review
- Review
- A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.Gut microbes · 2026Article
- Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Eggerthella lenta: metabolism, pathogenesis and therapeutic implications.Nature reviews. Microbiology · 2026Review
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Bile acid signaling in health and disease.Molecular biomedicine · 2026Review
- Intestinal HIF1α is dispensable for bariatric surgery-mediated metabolic benefits but protects against diet-induced obesity and hepatic steatosis.International journal of obesity (2005) · 2026Article
- Ageing processes in the bonobo gut microbiome mirror human patterns.NPJ biofilms and microbiomes · 2026Article
- The urinary pathobiont Actinobaculum massiliense can generate androgens via the dirAB pathway.Nature communications · 2026Article
- Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health.Biomedicines · 2026Review
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Metabolic Profiling of Epigenetic Aging and Its Associations With Aging-Related Phenotypes and Modifiable Lifestyle Factors.Aging cell · 2026Article
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Gut Microbiota-Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1-Mediated Parthanatos.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrating Network Pharmacology and Metabolomics to Decipher the Mechanisms Underlying the Therapeutic Effects of Wuzhi Dripping Pills Against MASLD.Metabolites · 2026Article
- Synergistic synbiotic therapies for ulcerative colitis: mechanistic insights from multi-targeted pathways in animal models.Inflammopharmacology · 2026Review
315 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors.
Yuko Sato *Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2177-5820
Koji Atarashi *Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5422-0736
Damian R Plichta *Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6555-2557
Yasumichi AraiCentre for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Satoshi SasajimaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Sean M KearneyDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Wataru SudaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kozue TakeshitaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Takahiro SasakiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
Shoki OkamotoDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Ashwin N SkellyDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1565-3376
Yuki OkamuraDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Hera VlamakisInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1086-9191
Youxian LiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takeshi TanoueDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3639-8834
Hajime TakeiJunshin Clinic Bile Acid Institute, Tokyo, Japan.
Hiroshi NittonoJunshin Clinic Bile Acid Institute, Tokyo, Japan.
Seiko NarushimaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Junichiro IrieDepartment of Internal Medicine, Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2662-4121
Hiroshi ItohDepartment of Internal Medicine, Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo, Japan.
Kyoji MoriyaDepartment of Infection Control and Prevention, The University of Tokyo, Tokyo, Japan.
Yuki SugiuraDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Makoto SuematsuDepartment of Biochemistry, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7165-6336
Nobuko MoritokiElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Shinsuke ShibataElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1185-9043
Dan R LittmanThe Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Michael A FischbachDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3079-8247
Yoshifumi UwaminoDepartment of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
Takashi InoueDepartment of Marmoset Biology and Medicine, Central Institute for Experimental Animals, Kawasaki, Japan.ORCID http://orcid.org/0000-0003-4691-7255
Akira HondaDivision of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.ORCID http://orcid.org/0000-0003-0902-8272
Masahira HattoriRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Tsuyoshi MuraiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
Ramnik J XavierInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5167
Nobuyoshi HiroseCentre for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Kenya HondaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan. kenya@keio.jp.ORCID http://orcid.org/0000-0001-8937-9835
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MNIDDK NIH HHS P30 DK043351
Abstract
Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases
Indexed as
Biosynthetic PathwaysCentenariansGastrointestinal Microbiome3-Hydroxysteroid DehydrogenasesAged, 80 and overAnimalsAnti-Bacterial AgentsBacteriaCholestenone 5 alpha-ReductaseFecesFemaleGram-Positive BacteriaHumansLithocholic AcidMaleMice3-Hydroxysteroid DehydrogenasesAnti-Bacterial AgentsCholestenone 5 alpha-ReductaseLithocholic Acid
Identifiers
PMID
34325466What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.