ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022
Trends in Early-onset vs Late-onset Colorectal Cancer Incidence by Race/Ethnicity in the United States Cancer Statistics Database.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- At what age should people with obesity start colorectal cancer screening?International journal of cancer · 2026Pooled it
- The histological and molecular characteristics of early-onset colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Patient experiences and unmet needs in diagnosis and treatment of metastatic colorectal cancer: results of a US survey.Future oncology (London, England) · 2026Article
- The rapid surge of colorectal cancer in children and young adults: a 22-year analysis of the CDC WONDER database.Proceedings (Baylor University. Medical Center) · 2026Article
- Review
- Decoding notch signaling pathway: an updated insight into its role in colorectal cancer progression and therapy.Cancer cell international · 2026Review
- Characteristics and Prognosis of Early-Onset vs. Late-Onset Colon Cancer: A Propensity Score Matching Analysis Based on Histology.Cancer medicine · 2026Article
- Trends in Early-Onset Colorectal Adenocarcinoma and Neuroendocrine Tumors Across Racial and Ethnic Groups.Journal of clinical medicine · 2026Article
- Clinicopathologic features and prognostic factors in early- versus late-onset colorectal cancer: a stage-stratified retrospective surgical cohort from the Mekong Delta, Vietnam.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Article
- Early and late-onset colorectal cancer in African Americans during COVID-19.World journal of gastrointestinal oncology · 2025Article
- de novo metastases in patients with primary colorectal cancer: a Surveillance, Epidemiology, and End Results analysis.Cancer causes & control : CCC · 2025Article
- Evaluating Risk Factors for Early-Onset Colorectal Cancer in a Large, Prospective Cohort.Digestive diseases and sciences · 2025Article
- Trends in the prevalence of early-onset cancer and associated early-life exposures among US adults: A serial cross-sectional study.Preventive medicine reports · 2025Article
- Conventional screening measure does not accurately capture screening status in a minority of patients with colorectal cancer.Medicine · 2025Observational
- Colorectal endoscopic submucosal dissection in the USA: The current state and future perspectives.DEN open · 2025Review
- Impact of Small Area Level Deprivation on Colorectal Cancer Survival: Findings from the Regional Cancer Registry in Korea.Cancers · 2025Article
- Mutational and co-mutational landscape of early onset colorectal cancer.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025Article
- An update on the incidence rates of early onset vs late onset colon cancer among Whites, Blacks, Hispanics, and Asian-American/Pacific Islanders in the United States.Proceedings (Baylor University. Medical Center) · 2025Article
- The Impact of Nutritional Status and Tumor-Infiltrating Lymphocytes (CD4+ and CD8+) on Chemotherapy Response in Colorectal Cancer Patients.Cancer management and research · 2025Article
- Area Socioeconomic Status and Early Onset Rectal Cancer in a Comprehensive Cancer Center: Evidence from Wisconsin.WMJ : official publication of the State Medical Society of Wisconsin · 2025Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsColorectal cancer (CRC) incidence has decreased overall in the last several decades, but it has increased among younger adults. Prior studies have characterized this phenomenon in the United States (U.S.) using only a small subset of cases. We describe CRC incidence trends using high-quality data from 92% of the U.S. population, with an emphasis on those younger than 50 years.
methodsWe obtained 2001 to 2016 data from the U.S. Cancer Statistics database and analyzed CRC incidence for all age groups, with a focus on individuals diagnosed at ages 20 to 49 years (early-onset CRC). We compared incidence trends stratified by age, as well as by race/ethnicity, sex, region, anatomic site, and stage at diagnosis.
resultsWe observed 191,659 cases of early-onset and 1,097,765 cases of late-onset CRC during the study period. Overall, CRC incidence increased in every age group from 20 to 54 years. Whites were the only racial group with a consistent increase in incidence across all younger ages, with the steepest rise seen after 2012. Hispanics also experienced smaller increases in incidence in most of the younger age groups. Asians/Pacific Islanders and blacks saw no increase in incidence in any age group in 2016, but blacks continued to have the highest incidence of CRC for every age group. Greater increase in early-onset CRC incidence was observed for males, left-sided tumors, and regional and distant disease.
conclusionsEarly-onset CRC incidence increased overall from 2001 to 2016, but the trends were markedly different for whites, blacks, Asians/Pacific Islanders, and Hispanics. These results may inform future research on the risk factors underlying early-onset CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.