Evidence map›Paper›PMID 34324980›Full record

ArticleFree radical biology & medicine2021

CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage.

Le P Ngo, Simran Kaushal, Isaac A Chaim, Patrizia Mazzucato, Catherine Ricciardi, Leona D Samson, Zachary D Nagel, Bevin P Engelward

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Le P NgoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Simran KaushalDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. Electronic address: kaushal@mit.edu.
Isaac A ChaimDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: iachaim@ucsd.edu.
Patrizia MazzucatoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: patrizia.mazzucato@gmail.com.
Catherine RicciardiMIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Clinical Research Center, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: c_ricci@mit.edu.
Leona D SamsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: lsamson@mit.edu.
Zachary D NagelDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. Electronic address: znagel@hsph.harvard.edu.
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; MIT Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: bevin@mit.edu.
Center for Environmental Health · USHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stuart S Levine · 2017 to 2026
$22.2M
Multi-Pathway DNA Repair Capacity Measurements in Lung Cancer Patients and Healthy ControlsU01ES029520 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHRISTIANI, DAVID C, ENGELWARD, BEVIN P. · 2018 to 2022
$3.3M
Developing novel methods to measure DNA repair capacity in human populationsDP1ES022576 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAMSON, LEONA D. · 2012 to 2013
$1.6M
NIEHS NIH HHS DP1 ES022576NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS U01 ES029520
6 · The paper itself

Abstract

Although DNA repair is known to impact susceptibility to cancer and other diseases, relatively few population studies have been performed to evaluate DNA repair kinetics in people due to the difficulty of assessing DNA repair in a high-throughput manner. Here we use the CometChip, a high-throughput comet assay, to explore inter-individual variation in repair of oxidative damage to DNA, a known risk factor for aging, cancer and other diseases. DNA repair capacity after H

Indexed as

Hydrogen PeroxideLeukocytes, MononuclearComet AssayDNA DamageDNA RepairHumansIndividualityKineticsLymphocytesOxidative StressHydrogen PeroxideCometChipDNA damageDNA repairRepair kinetics

Identifiers

PMID34324980
PMCPMC8477454
OpenAlexW3185638259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.