ArticleReproductive toxicology (Elmsford, N.Y.)2021
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice.
Article in Reproductive toxicology (Elmsford, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Exploring offspring behaviour after prenatal COVID-19 vaccination in mice.Translational psychiatry · 2026Article
- A replication-incompetent adenovirus type 55 vaccine induces broad and durable protective immunity against pathogenic adenoviruses.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspring.Scientific reports · 2025Article
- A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals.Archives of toxicology · 2024Review
- Fertility outcomes in women undergoing Assisted Reproductive Treatments after COVID-19 vaccination: A prospective cohort study.International journal of fertility & sterility · 2024Article
- Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review.Annals of medicine · 2023Review
- Maternal and neonatal outcomes of COVID-19 vaccination during pregnancy, a systematic review and meta-analysis.NPJ vaccines · 2023Review
- Impact of COVID-19 Vaccination on Pregnant Women.Pathogens (Basel, Switzerland) · 2023Review
- Review
- Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes.Current topics in microbiology and immunology · 2023Article
- Investigating Impacts of CoronaVac Vaccination in Males onThe world journal of men's health · 2022Article
- COVID-19, Vaccination, and Female Fertility in the Czech Republic.International journal of molecular sciences · 2022Article
- Insights into COVID-19 vaccines development: Translation from benchside to bedside.Health sciences review (Oxford, England) · 2022Review
- Article
- Covid-19 vaccination in pregnancy.BMJ (Clinical research ed.) · 2022Review
- Corona and Reproduction, or Why the Corona Vaccination Does Not Result in Infertility.Geburtshilfe und Frauenheilkunde · 2022Article
- Effective Communication About Pregnancy, Birth, Lactation, Breastfeeding and Newborn Care: The Importance of Sexed Language.Frontiers in global women's health · 2022Article
- Addressing COVID-19 vaccine hesitancy.Drugs in context · 2022Review
- SARS-CoV-2 Spike Protein ExpressionFrontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AZD1222 (ChAdOx1 nCoV-19) is a COVID-19 vaccine that is not yet licensed for use during pregnancy. To support the inclusion of pregnant and breastfeeding people in AZD1222 clinical studies, a non-clinical developmental and reproductive toxicity study was performed to evaluate its effects on fertility and reproductive processes of female CD-1 mice during the embryofetal development phase, and postnatal outcomes during the littering phase. Immunogenicity assessments were also made in dams, fetuses, and pups. There were no vaccine-related unscheduled deaths throughout the study. Furthermore, there were no vaccine-related effects on female reproduction, fetal or pup survival, fetal external, visceral, or skeletal findings, pup physical development, and no abnormal gross pathology findings in pups or dams. Antibody responses raised in dams were maintained throughout gestation and postnatal periods, and seroconversion in fetuses and pups indicate placental and lactational transfer of immunoglobulins. Together with clinical data from non-pregnant people, these results support the inclusion of pregnant and breastfeeding people in AZD1222 clinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.