ArticleThe Journal of pediatrics2021
Kawasaki Disease and Pediatric Infectious Diseases During the Coronavirus Disease 2019 Pandemic.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Epidemiology of Kawasaki Disease After the COVID-19 Pandemic in Japan 2023-2024.JAMA network open · 2026Article
- Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.Current issues in molecular biology · 2026Article
- Prenatal and postnatal risk factors associated with Kawasaki disease up to 3 years of age.Scientific reports · 2026Article
- Did the COVID-19 pandemic change the Kawasaki disease phenotype? Observations from the International Kawasaki Disease Registry.Pediatric cardiology · 2026Article
- Ozone exposure is positively correlated with the occurrence of Kawasaki disease in Chinese children.Pediatric research · 2026Article
- Kawasaki disease and outdoor environmental stressors: a scoping review.The Lancet regional health. Western Pacific · 2026Review
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
- Clinical characteristics and trend changes of Kawasaki disease in children because of the Omicron pandemic.Italian journal of pediatrics · 2025Article
- Add in a virus: four cases of severe Kawasaki disease and concurrent adenovirus infection.BMC pediatrics · 2025Article
- Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades.Laboratory investigation; a journal of technical methods and pathology · 2025Article
- Frequency of SARS-CoV-2 antecedent infection in patients with Kawasaki disease.Nagoya journal of medical science · 2025Observational
- Kawasaki disease before and during the COVID-19 pandemic: a single-center comparative study in Switzerland.BMC pediatrics · 2024Article
- The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024Review
- Age-Dependent Variations in Kawasaki Disease Incidence in Japan.JAMA network open · 2024Article
- Decreased incidence of Kawasaki disease in South Korea during the SARS-CoV-2 pandemic.Frontiers in pediatrics · 2024Article
- Maternal Serum Folic Acid Levels and Onset of Kawasaki Disease in Offspring During Infancy.JAMA network open · 2023Article
- Analysis of Plasmablasts From Children With Kawasaki Disease Reveals Evidence of a Convergent Antibody Response to a Specific Protein Epitope.The Journal of infectious diseases · 2023Article
- Unexpectedly high incidence of Kawasaki Disease in a Canadian Atlantic Province- an 11-year retrospective descriptive study.Pediatric rheumatology online journal · 2023Article
- T Cell Receptor Sequences Amplified during Severe COVID-19 and Multisystem Inflammatory Syndrome in Children Mimic SARS-CoV-2, Its Bacterial Co-Infections and Host Autoantigens.International journal of molecular sciences · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the epidemiologic association between Kawasaki disease and common pediatric infectious diseases (PIDs) identified during the coronavirus disease 2019 (COVID-19) pandemic period to confirm whether the infection-triggered theory is a plausible hypothesis for the pathogenesis of Kawasaki disease. STUDY
designA retrospective epidemiologic study was conducted using datasets obtained from Web-based surveillance of Kawasaki disease and PIDs in Japan. We compared weekly numbers of patients who developed Kawasaki disease and specific PIDs between 2020 and 2017-2019 and evaluated the association between the percent reduction in the number of patients with these diseases.
resultsA total of 868 patients developed Kawasaki disease in 2020. During the social distancing period in 2020, the number of patients with Kawasaki disease was approximately 35% lower than in 2017-2019. Time from the onset of Kawasaki disease until the first hospital visit did not differ significantly among the examined years. The proportion of older children with Kawasaki disease decreased more than that of infants with Kawasaki disease (age <1 year), resulting in a significant difference in the proportion of infant patients between 2020 and 2017-2019 (24% vs 19%; P < .01). The number of patients with incomplete Kawasaki disease was unchanged from that of previous years. The weekly percent reduction in patient numbers differed between Kawasaki disease and PIDs during 2020, with no strong correlation between the 2 diseases.
conclusionsOur data indicate that parents of patients with Kawasaki disease did not avoid hospital visits during the COVID-19 pandemic period. The findings indicate the possibility that triggering Kawasaki disease might be associated with presently unidentified respiratory pathogen(s) that potentially might be acquired from both within and outside the household.
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