ArticlePloS one2021
The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of a New Combination of Antibiofilm Enzymes, Antiadhesive Agents, and Liquorice Extracts on Plaque Accumulation in Dogs: An Unicenter, Controlled, and Randomized Study.Journal of veterinary dentistry · 2026Article
- Feline comorbidities: cardiovascular and kidney diseases.Journal of feline medicine and surgery · 2026Review
- Moderate to advanced periodontitis contributes to increased oxidative stress in cats: a case-control study.BMC veterinary research · 2024Article
- Developing diagnostic tools for canine periodontitis: combining molecular techniques and machine learning models.BMC veterinary research · 2023Article
- Molecular Microbiological Characteristics of Gingival Pockets in the Periodontal Diseases of Dogs.Journal of veterinary research · 2023Article
- Novel renal injury markers in dogs with ehrlichiosis.PloS one · 2023Article
- Clinical importance of borderline proteinuria in nonazotemic cats and evaluation of other risk factors for the development of chronic kidney disease.Journal of veterinary internal medicineArticle
- Urinary cystatin B differentiates progressive versus stable IRIS Stage 1 chronic kidney disease in dogs.Journal of veterinary internal medicineArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the benefits and inherent risks of dental cleaning procedures, based on serum and urine biomarkers for kidney function and tissue damage, in dogs and cats. Thirty-one asymptomatic, mostly older dogs (14 neutered male and 17 ovariohysterectomized female dogs of various breeds between 3 and 14 years old) and cats (19 neutered male and 12 ovariohysterectomized female domestic short hair cats between 2 and 16 years old) diagnosed with periodontal disease on physical exam, and recommended by their veterinarian to have dental cleaning under general anesthesia were evaluated in a prospective study. Serum and urine samples were collected from dogs and cats 1 week before, 6 hours after, and again 1 week after the dental cleaning procedure. Samples were analyzed for biomarkers of kidney function [serum creatinine (Cr), symmetric dimethylarginine (SDMA), and blood urea nitrogen (BUN), and urine for specific gravity (USG) and protein:creatinine (UPC) ratio]. A panel of biomarkers for renal tissue damage was also assessed [serum β-aminoisobutyric acid (BAIB), and urine cystatin B and clusterin]. Samples collected one week before dental cleaning procedures showed that increased age and severity of dental disease were linked to abnormal kidney function biomarker values (age: elevated SDMA and Cr concentrations and isosthenuric USG values; disease severity: elevated UPC ratios) as well as elevated urine cystatin B and clusterin concentrations. Directly after the dental cleaning procedure, an increased number of cats with elevated SDMA concentrations was observed (specifically in cats with longer duration of dental procedures). Extended duration of dental procedures (≥60 min) was linked to increased urine cystatin B and clusterin concentrations, whereas shorter duration procedures was linked to decreased urine cystatin B and clusterin. Higher SDMA concentrations persisted in cats one week after the dental cleaning procedures and were linked to elevated UPC ratios one week before cleaning procedures. In conclusion, the results of this study indicate a link between severity of dental disease, renal tissue injury, and impaired renal function. Longer duration dental procedures in cats may carry inherent risks of kidney injury and impaired renal function.
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