ArticlePloS one2021
A prospective cross-sectional study of tuberculosis in elderly Hispanics reveals that BCG vaccination at birth is protective whereas diabetes is not a risk factor.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Interaction between type 2 diabetes and past COVID-19 on active tuberculosis.BMC infectious diseases · 2024Article
- Picking the low-hanging fruit: the cost-effectiveness of opportunistic diabetes screening during tuberculosis contact investigations on the Texas-Mexico border.BMJ public health · 2024Article
- High all-cause mortality and increasing proportion of older adults with tuberculosis in Texas, 2008-2020.Epidemiology and infection · 2024Article
- Prevalence of pulmonary tuberculosis among casual labourers working in selected road construction sites in central Uganda.PloS one · 2024Article
- Strong effect of demographic changes on Tuberculosis susceptibility in South Africa.PLOS global public health · 2024Article
- Strong Effect of Demographic Changes on Tuberculosis Susceptibility in South Africa.medRxiv : the preprint server for health sciences · 2023Article
- The differences in drug resistance between drug-resistant tuberculosis patients with and without diabetes mellitus in northeast China: a retrospective study.BMC infectious diseases · 2023Article
- Differential Role of Type 2 Diabetes as a Risk Factor for Tuberculosis in the Elderly versus Younger Adults.Pathogens (Basel, Switzerland) · 2022Article
- Review
- Clinical significance of CA-125 in elderly patients with active pulmonary tuberculosis: A retrospective study.Saudi medical journal · 2022Article
- Tuberculosis in an Aging World.Pathogens (Basel, Switzerland) · 2022Review
- The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections.Frontiers in aging · 2022Review
- Interferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAging increases the risk of tuberculosis (TB) and its adverse outcomes, but most studies are based on secondary analyses, and few are in Hispanics. Diabetes is a risk factor for TB in adults, but its contribution in the elderly is unknown. We aimed to identify the role of diabetes and other risk factors for TB in elderly Hispanics.
methodsCross-sectional study among newly-diagnosed TB patients, recent contacts (ReC), or community controls (CoC) totaling 646 participants, including 183 elderly (>60 years; 43 TB, 80 ReC, 60 CoC) and 463 adults (18 to 50 years; 80 TB, 301 ReC and 82 CoC). Host characteristics associated with TB and latent Mycobacterium tuberculosis infection (LTBI) were identified in the elderly by univariable and confirmed by multivariable logistic regression.
resultsLTBI was more prevalent among the elderly CoC (55% vs. 23.2% in adults; p<0.001), but not in ReC (elderly 71.3% vs. adult 63.8%); p = 0.213). Risk factors for TB in the elderly included male sex (adj-OR 4.33, 95% CI 1.76, 10.65), smoking (adj-OR 2.55, 95% CI 1.01, 6.45) and low BMI (adj-OR 12.34, 95% CI 4.44, 34.33). Unexpectedly, type 2 diabetes was not associated with TB despite its high prevalence (adj-OR 0.38, 95% CI 0.06, 2.38), and BCG vaccination at birth was protective (adj-OR 0.16, 95% CI 0.06, 0.45).
conclusionsWe report novel distinctions in TB risk factors in the elderly vs. adults, notably in diabetes and BCG vaccination at birth. Further studies are warranted to address disparities in this vulnerable, understudied population.
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