Evidence map›Paper›PMID 34324429›Full record

ArticleEuropean journal of endocrinology2021

Circadian rhythms of 11-oxygenated C19 steroids and ∆5-steroid sulfates in healthy men.

Adina F Turcu, Lili Zhao, Xuan Chen, Rebecca Yang, Juilee Rege, William E Rainey, Johannes D Veldhuis, Richard J Auchus

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06505278 (The Impact of Circadian Rhythm-Based Medication Timing Adjustment on the Efficacy and Safety of Novel Hormonal Therapy), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06505278 phase2not yet recruitingnot on this mapstarted 2024, after this paper: background citation

The Impact of Circadian Rhythm-Based Medication Timing Adjustment on the Efficacy and Safety of Novel Hormonal Therapy

TypeinterventionalSponsorSun Yat-sen UniversityRan2024 to 2025Enrolled70ConditionsProstate CancerArmsReceive Abiraterone plus prednisone/Enzalutamide/Apalutamide/Rezvilutamide in the evening
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. 24-Hour Profiles of 11-Oxygenated CFrontiers in endocrinology · 2021
    Trial
  2. Article
  3. Article
  4. Article
  5. Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.International journal of environmental research and public health · 2023
    Article
  6. The role of 11-oxygenated androgens in prostate cancer.Endocrine oncology (Bristol, England) · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adina F TurcuDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9831-6190
Lili ZhaoSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Xuan ChenSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Rebecca YangEndocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA.
Juilee RegeDepartment of Physiology and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.
William E RaineyDepartment of Physiology and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.
Johannes D VeldhuisEndocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA.
Richard J AuchusDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Molecular Mechanisms of AdrenarcheR01DK069950 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAINEY, WILLIAM E · 2005 to 2019
$4.4M
The contemporary endocrinology of congenital adrenal hyperplasiaK08DK109116 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2016 to 2020
$832k
NIDDK NIH HHS K08 DK109116NIDDK NIH HHS R01 DK069950
6 · The paper itself

Abstract

backgroundMany hormones display distinct circadian rhythms, driven by central regulators, hormonal bioavailability, and half-life. A set of 11-oxygenated C19 steroids (11-oxyandrogens) and pregnenolone sulfate (PregS) are elevated in congenital adrenal hyperplasia and other disorders, but their circadian patterns have not been characterized. PARTICIPANTS AND

methodsPeripheral blood was collected every 2 h over 24 h from healthy volunteer men (10 young, 18-30 years, and 10 older, 60-80 years). We used mass spectrometry to quantify 15 steroids, including androstenedione (A4), testosterone (T), 11β-hydroxy- and 11-ketotestosterone (11OHT, 11KT),11β-hydroxy- and 11-ketoandrostenedione (11OHA4, 11KA4), and 4 ∆5-steroid sulfates. Diurnal models including mesor (rhythm adjusted median), peak, and nadir concentrations, acrophase, and amplitude were computed.

results11OHA4 followed a rhythm similar to cortisol: acrophase 8:00 h, nadir 21:00 h and were similar in young and old men. 11KT had similar diurnal patterns, but the peak was lower in older than in young men, as was the case for A4. All four steroid sulfates were higher in young vs older men. PregS and 17-hydroxypregnenolone sulfate (17OHPregS) showed sustained elevations between 8:00 and 18:00 h, and nadirs around midnight, while DHEAS and AdiolS displayed minimal diurnal variations. All 4 11-oxyandrogens correlated tightly with cortisol (r from 0.54 for 11OHT to 0.81 for 11OHA4, P < 0.0001 for all), but very weakly with T, supporting their adrenal origin and ACTH governance.

conclusions11-Oxyandrogens, PregS, and 17OHPregS display distinct circadian and age variations, which should be accounted for when used as clinical biomarkers.

Indexed as

AdolescentAdultAgedAged, 80 and overAgingAndrogensBlood Chemical AnalysisCircadian RhythmHealthy VolunteersHumansHydroxysteroidsKetosteroidsMaleMass SpectrometryMiddle AgedSulfatesAndrogensHydroxysteroidsKetosteroidsSulfates

Identifiers

PMID34324429
PMCPMC8826489

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.