Evidence map›Paper›PMID 34324289›Full record

ArticleACS chemical neuroscience2021

Tyrosine

YashoNandini Singh, David Ormaza, Alessandra Massetti, Dmitriy Minond, Maré Cudic

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Dynamic glycosylation remodeling in neurological disorders.Frontiers in molecular neuroscience · 2025
    Review
  4. Article
  5. Review
  6. Mucin-TypeFrontiers in chemistry · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

YashoNandini SinghDepartment of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.ORCID 0000-0002-1186-3376
David OrmazaDepartment of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
Alessandra MassettiDepartment of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.
Dmitriy MinondCollege of Pharmacy and Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, 3301 College Ave, Fort Lauderdale, Florida 33314, United States.
Maré CudicDepartment of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.ORCID 0000-0002-7657-0400
Florida Atlantic University · USNova Southeastern University · US

Funding

Mechanistic insight into tumor-associated MUC1 glycopeptides binding to macrophage galactose-type lectinR15CA242351 · NCI · FLORIDA ATLANTIC UNIVERSITY · PI CUDIC, MARE · 2019 to 2024
$878k
In vivo efficacy evaluation of novel melanoma activesR15CA249788 · NCI · NOVA SOUTHEASTERN UNIVERSITY · PI MINOND, DMITRIY · 2020 to 2020
$453k
NCI NIH HHS R15 CA242351NCI NIH HHS R15 CA249788
6 · The paper itself

Abstract

The amyloid-β precursor protein (APP) undergoes proteolytic cleavage by α-, β-, and γ-secretases, to determine its fate in Alzheimer's disease (AD) pathogenesis. Recent findings suggest a possible role of

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesGlycopeptidesHumansTyrosineAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesGlycopeptidesTyrosineAlzheimer’s disease (AD)APPCD analysisO-glycosylationproteolytic cleavagetyrosine

Identifiers

PMID34324289
PMCPMC8378340
OpenAlexW3184874805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.