Evidence map›Paper›PMID 34324252›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2022

Assessing the added value of group B Streptococcus maternal immunisation in preventing maternal infection and fetal harm: population surveillance study.

T Lamagni, C Wloch, K Broughton, S M Collin, V Chalker, J Coelho, S N Ladhani, C S Brown, N Shetty, A P Johnson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
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  5. Colonisation of Group BBMJ open · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

T LamagniHealthcare-Associated Infection & Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.ORCID 0000-0002-3965-8323
C WlochHealthcare-Associated Infection & Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
K BroughtonRespiratory and Vaccine Preventable Reference Unit, Bacteriology Reference Department, National Infection Service, Public Health England, London, UK.
S M CollinHealthcare-Associated Infection & Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
V ChalkerRespiratory and Vaccine Preventable Reference Unit, Bacteriology Reference Department, National Infection Service, Public Health England, London, UK.
J CoelhoRespiratory and Vaccine Preventable Reference Unit, Bacteriology Reference Department, National Infection Service, Public Health England, London, UK.
S N LadhaniImmunisation and Countermeasures Division, National Infection Service, Public Health England, London, UK.
C S BrownHealthcare-Associated Infection & Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
N ShettyRespiratory and Vaccine Preventable Reference Unit, Bacteriology Reference Department, National Infection Service, Public Health England, London, UK.
A P JohnsonHealthcare-Associated Infection & Antimicrobial Resistance Division, National Infection Service, Public Health England, London, UK.
Public Health England · GB

Funding

PHE
6 · The paper itself

Abstract

objectiveTo assess the incidence of maternal group B Streptococcus (GBS) infection in England.

designPopulation surveillance augmented through data linkage.

settingEngland. POPULATION: All pregnant women accessing the National Health Service (NHS) in England.

methodsInvasive GBS (iGBS) infections during pregnancy or within 6 weeks of childbirth were identified by linking Public Health England (PHE) national microbiology surveillance data for 2014 to NHS hospital admission records. Capsular serotypes of GBS were determined by reference laboratory typing of clinical isolates from women aged 15-44 years. Post-caesarean section surgical site infection (SSI) caused by GBS was identified in 21 hospitals participating in PHE SSI surveillance (2009-2015).

main outcome measuresiGBS rate per 1000 maternities; risk of GBS SSI per 1000 caesarean sections.

resultsOf 1601 patients diagnosed with iGBS infections in England in 2014, 185 (12%) were identified as maternal infections, a rate of 0.29 (95% CI 0.25-0.33) per 1000 maternities and representing 83% of all iGBS cases in women aged 18-44 years. Seven (3.8%) were associated with miscarriage. Fetal outcome identified excess rates of stillbirth (3.4 versus 0.5%) and extreme prematurity (<28 weeks of gestation, 3.7 versus 0.5%) compared with national averages (P < 0.001). Caesarean section surveillance in 27 860 women (21 hospitals) identified 47 cases of GBS SSI, with an estimated 4.24 (3.51-5.07) per 1000 caesarean sections, a median time-to-onset of 10 days (IQR 7-13 days) and ten infections that required readmission. Capsular serotype analysis identified a diverse array of strains with serotype III as the most common (43%).

conclusionsOur assessment of maternal GBS infection in England indicates the potential additional benefit of GBS vaccination in preventing adverse maternal and fetal outcomes.

Indexed as

Prenatal CareAdolescentAdultEnglandFemaleHospitalizationHumansInfant, NewbornInfant, Newborn, DiseasesMedical RecordsPopulation SurveillancePregnancyPregnancy Complications, InfectiousState MedicineStreptococcal InfectionsStreptococcus agalactiaeEnglandethnic groupsinfectiouspopulation surveillancepregnancy complicationsStreptococcus agalactiaesurgical wound infection

Identifiers

PMID34324252
PMCPMC9291181
OpenAlexW3184624958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.