Evidence map›Paper›PMID 34324182›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts.

Emilie M Legault, Janelle Drouin-Ouellet

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emilie M LegaultFaculté de Pharmacie, Université de Montréal, Montreal, QC, Canada.
Janelle Drouin-OuelletFaculté de Pharmacie, Université de Montréal, Montreal, QC, Canada. janelle.drouin-ouellet@umontreal.ca.
Université de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the first demonstration of direct dopaminergic neuronal reprogramming, over a dozen methods have been developed to generate induced dopaminergic neurons from various sources of cells. Here, we first present an overview of the different methods to generate induced neurons of a generic type and of different subtypes, with a particular focus on induced dopaminergic neurons generated from human fibroblasts. We then describe a protocol to generate induced dopaminergic neurons from commercially available human fetal lung fibroblasts. These cells could serve for various biomedical application, including regenerative medicine for conditions such as Parkinson's disease.

Indexed as

Cell TransdifferentiationCellular ReprogrammingCellular Reprogramming TechniquesCell DifferentiationCell LineCells, CulturedDopaminergic NeuronsFibroblastsGene ExpressionGenetic VectorsHumansLentivirusTranscription FactorsTranscription FactorsDirect reprogrammingDopaminergic neuronsHuman fetal fibroblastsInduced neuronsTranscription factorsViral vectors

Identifiers

PMID34324182
OpenAlexW3183251193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.