Evidence map›Paper›PMID 34324179›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Direct Reprogramming of Fibroblasts to Astrocytes Using Small Molecules.

E Tian, Mingzi Zhang, Yanhong Shi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

E Tian *Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Mingzi Zhang *Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Yanhong ShiDivision of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA. yshi@coh.org.
Beckman Research InstituteCity of Hope · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
ApoE2 in Alzheimer's disease: the neuroprotective effects and mechanismsRF1AG061794 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2018 to 2018
$3.1M
Modeling Alzheimer’s disease using directly reprogrammed isogenic neural cellsR01AG056305 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, YADONG, SHI, YANHONG · 2017 to 2021
$2.2M
Uncovering the molecular and cellular mechanisms underlying AD using CRISPR/Cas9-edited isogenic neural cellsR56AG061171 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2019 to 2019
$629k
NCI NIH HHS P30 CA033572NIA NIH HHS R01 AG056305NIA NIH HHS R56 AG061171NIA NIH HHS RF1 AG061794
6 · The paper itself

Abstract

Astrocytes play important roles in neurodevelopment and diseases. Previous studies described ways to derive astrocytes from somatic cells by going through iPSC or iNSC/iNPC intermediates. Here we describe a method to directly convert mouse fibroblasts into functional astrocytes using small molecules without transgenes or viral transduction. The direct chemical reprogramming method described in this study provides a more rapid way to derive astrocytes from fibroblasts.

Indexed as

Cellular Reprogramming TechniquesAnimalsAstrocytesBiomarkersCell DifferentiationCells, CulturedCell SeparationCellular ReprogrammingFibroblastsGene ExpressionHumansImmunohistochemistryInduced Pluripotent Stem CellsMiceTranscription FactorsTransgenesBiomarkersTranscription FactorsChemical reprogrammingDirect conversionInduced astrocytesiPSC-derived astrocytesiPSCsSmall molecules

Identifiers

PMID34324179
PMCPMC10519582
OpenAlexW3185847506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.