ArticleThe Plant cell2021
The ubiquitin-interacting motif-type ubiquitin receptor HDR3 interacts with and stabilizes the histone acetyltransferase GW6a to control the grain size in rice.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- A wheat-specific proline-rich protein regulates grain weight through a ubiquitin-mediated delay of endosperm cellularization.The Plant journal : for cell and molecular biology · 2026Article
- Ubiquitination-Mediated Regulation of Brassinosteroid Signaling.Plants (Basel, Switzerland) · 2026Review
- The ubiquitin receptor StDA1 negatively regulates aurantio-obtusin biosynthesis by mediating the degradation of the StHDR1 protein in Senna tora seeds.Communications biology · 2026Article
- Epigenetic control of seed development and dormancy in cereals.Plant signaling & behavior · 2025Review
- The Phytochrome-Interacting Factor OsPIL11 Coordinates Grain Weight and Grain Number Via Directly Regulating the Expression of OsMIR530 and OsCKX2 in Rice.Rice (New York, N.Y.) · 2025Article
- Grain shape in rice: a Genome-wide association study of the effector genes.BMC plant biology · 2025Article
- The OsbZIP35-COR1-OsTCP19 module modulates cell proliferation to regulate grain length and weight in rice.Science advances · 2025Article
- CRISPR/Cas9-mediated disruption of DA1 enhances both biomass yield and quality in poplar.Plant biotechnology journal · 2025Article
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- Gene Pyramiding Strategies for Sink Size and Source Capacity for High-Yield Japonica Rice Breeding.Rice (New York, N.Y.) · 2025Review
- Unveiling the genetic architecture of barley embryo: QTL mapping, candidate genes identification and its relationship with kernel size and early vigour.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification of a novel locus qGW12/OsPUB23 regulating grain shape and weight in rice (Oryza sativa L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Candidate gene analysis of rice grain shape based on genome-wide association study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Charting the evolutionary path of the SUMO modification system in plants reveals molecular hardwiring of development to stress adaptation.The Plant cell · 2024Review
- Genetic analysis of yield components in buckwheat using high-throughput sequencing analysis and wild resource populations.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- The OsMOB1A-OsSTK38 kinase complex phosphorylates CYCLIN C, controlling grain size and weight in rice.The Plant cell · 2024Article
- The TaSnRK1-TabHLH489 module integrates brassinosteroid and sugar signalling to regulate the grain length in bread wheat.Plant biotechnology journal · 2024Article
- OsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate.Nature communications · 2024Article
- Haplotype-resolved genome assembly of the diploid Rosa chinensis provides insight into the mechanisms underlying key ornamental traits.Molecular horticulture · 2024Article
- A nonsynonymous mutation in BhLS, encoding an acyl-CoA N-acyltransferase leads to fruit and seed size variation in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For grain crops such as rice (Oryza sativa), grain size substantially affects yield. The histone acetyltransferase GRAIN WEIGHT 6a (GW6a) determines grain size and yield in rice. However, the gene regulatory network underlying GW6a-mediated regulation of grain size has remained elusive. In this study, we show that GW6a interacts with HOMOLOG OF DA1 ON RICE CHROMOSOME 3 (HDR3), a ubiquitin-interacting motif-containing ubiquitin receptor. Transgenic rice plants overexpressing HDR3 produced larger grains, whereas HDR3 knockout lines produce smaller grains compared to the control. Cytological data suggest that HDR3 modulates grain size in a similar manner to GW6a, by altering cell proliferation in spikelet hulls. Mechanistically, HDR3 physically interacts with and stabilizes GW6a in an ubiquitin-dependent manner, delaying protein degradation by the 26S proteasome. The delay in GW6a degradation results in dramatic enhancement of the local acetylation of H3 and H4 histones. Furthermore, RNA sequencing analysis and chromatin immunoprecipitation assays reveal that HDR3 and GW6a bind to the promoters of and modulate a common set of downstream genes. In addition, genetic analysis demonstrates that HDR3 functions in the same genetic pathway as GW6a to regulate the grain size. Therefore, we identified the grain size regulatory module HDR3-GW6a as a potential target for crop yield improvement.
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