ArticleClinical and translational medicine2021
The human melanoma proteome atlas-Defining the molecular pathology.
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Article in Clinical and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Spatial Proteomics as a Potential Decision-Support Layer for Early Melanoma: A Narrative Review.International journal of dermatology · 2026Review
- Proteoform medicine: characterizing and targeting protein forms in human disease.Nature reviews. Genetics · 2026Review
- Distant metastases of melanoma exhibit varying extent of intrapatient proteogenomic heterogeneity.Clinical and translational medicine · 2025Article
- Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies.Cancer · 2025Article
- Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT.Journal of proteome research · 2025Article
- Emerging Techniques in Spatial Multiomics: Fundamental Principles and Applications to Dermatology.The Journal of investigative dermatology · 2025Review
- Identification of genetic fingerprint of type I interferon therapy in visceral metastases of melanoma.Scientific reports · 2024Article
- Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts.Frontiers in oncology · 2024Article
- Mitochondrial and immune response dysregulation in melanoma recurrence.Clinical and translational medicine · 2023Article
- Review
- The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.Journal of proteome research · 2023Review
- The Transcriptome and Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related Asexual Reproduction.International journal of molecular sciences · 2022Article
- Illuminating the dark protein-protein interactome.Cell reports methods · 2022Review
- Cancer proteogenomics: current impact and future prospects.Nature reviews. Cancer · 2022Review
- Mapping the Melanoma Plasma Proteome (MPP) Using Single-Shot Proteomics Interfaced with the WiMT Database.Cancers · 2021Article
- Article
- Article
- Discovery in clinical and translational medicine.Clinical and translational medicine · 2021Article
- The human melanoma proteome atlas-Defining the molecular pathology.Clinical and translational medicine · 2021Article
Corrections and comments
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Authors and funding
57 authors at 17 institutions in 11 countries.
Lazaro Hiram BetancourtDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0001-8207-7041
Jeovanis GilDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0003-3601-3893
Yonghyo KimDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Viktória DomaDepartment of Pathology, Semmelweis University, Hungary.
Uğur ÇakırDepartment of Dermatology, Venerology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Aniel SanchezSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Jimmy Rodriguez MurilloDepartment of Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Magdalena KurasSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Indira Pla ParadaSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.ORCID 0000-0002-0839-7829
Yutaka SugiharaDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0002-4406-3017
Roger AppelqvistDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Elisabet WieslanderDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Charlotte WelinderDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Erika VelasquezSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.ORCID 0000-0002-2169-3315
Natália Pinto de AlmeidaClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lerund University, Lund, Sweden.
Nicole WoldmarClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lerund University, Lund, Sweden.
Matilda Marko-VargaDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Krzysztof PawłowskiSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
Jonatan ErikssonDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Beáta SzeitzDepartment of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-6414-0537
Bo BaldetorpDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Christian IngvarSUS University Hospital Lund, Lund, Sweden.
Håkan OlssonDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Lotta LundgrenDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Henrik LindbergDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Henriett OskolasDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Boram LeeDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Ethan BergeDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Marie SjögrenDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Carina ErikssonDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Dasol KimChemical Genomics Global Research Lab, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Ho Jeong KwonChemical Genomics Global Research Lab, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.ORCID 0000-0002-6919-833X
Beatrice KnudsenDepartment of Pathology, University of Utah, Salt Lake City, USA.
Melinda RezeliClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lerund University, Lund, Sweden.
Runyu HongDepartment of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Grossman School of Medicine, New York, USA.ORCID 0000-0002-0941-351X
Peter HorvatovichDepartment of Analytical Biochemistry, Faculty of Science and Engineering, University of Groningen, Groningen, The Netherlands.
Tasso MiliotisTranslational Science and Experimental Medicine, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Toshihide NishimuraDepartment of Oncology, St. Marianna University School of Medicine, Kanagawa, Japan.
Harubumi KatoDepartment of Surgery, Tokyo Medical University, Tokyo, Japan.
Erik SteinfelderThermoFisher Scientific, HQ, San Jose, California, USA.
Madalina OppermannThermoFisher Scientific, HQ, San Jose, California, USA.
Ken MillerThermoFisher Scientific, HQ, San Jose, California, USA.
Francesco FlorindiBBMRI-ERIC HQ, Graz, Austria.
Qimin ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Gilberto B DomontChemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana PizzattiChemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fábio C S NogueiraChemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-5507-7142
Peter HorvathSynthetic and Systems Biology Unit, Biological Research Center, Szeged, Hungary.
Leticia SzadaiDepartment of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
József TímárDepartment of Pathology, Semmelweis University, Hungary.
Sarolta KárpátiDepartment of Dermatology, Venerology and Dermatooncology, Semmelweis University, Budapest, Hungary.
A Marcell SzászDepartment of Bioinformatics, Semmelweis University, Budapest, Hungary.
Johan MalmSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
David FenyöDepartment of Biochemistry and Molecular Pharmacology, Institute for Systems Genetics, New York University Grossman School of Medicine, New York, USA.
Henrik EkedahlDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
István Balázs NémethDepartment of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
György Marko-VargaClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lerund University, Lund, Sweden.
Lund University · SESemmelweis University · HUUniversidade Federal do Rio de Janeiro · BRThermo Fisher Scientific (United States) · USNew York University · USTokyo Medical University · JPUniversity of Szeged · HUYonsei University · KRAstraZeneca (Japan) · JPBiobanking and Biomolecular Resources Research Infrastructure Consortium · ATHUN-REN Szegedi Biológiai Kutatóközpont · HUKarolinska Institutet · SEShanghai Jiao Tong University · CNSt. Marianna University School of Medicine · JPUniversity of Groningen · NLUniversity of Utah · USWarsaw University of Life Sciences · PL
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
Indexed as
AdultAgedAged, 80 and overCell Line, TumorChromatography, High Pressure LiquidCutaneous Malignant MelanomaFemaleHumansMaleMelanomaMiddle AgedProteomeProteomicsSkin NeoplasmsTandem Mass SpectrometryYoung AdultProteomeheterogeneityhistopathologymetastatic malignant melanomaproteogenomicssubcellular localization
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.