Evidence map›Paper›PMID 34323215›Full record

ArticleeLife2021

Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.

Stephen M Blazie, Seika Takayanagi-Kiya, Katherine A McCulloch, Yishi Jin

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  12. Life science alliance · 2024
    Article
  13. Article
  14. Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications.International journal of molecular sciences · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephen M BlazieSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, United States.ORCID 0000-0001-6701-6275
Seika Takayanagi-KiyaSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, United States.
Katherine A McCullochSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, United States.
Yishi JinSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, United States.ORCID 0000-0002-9371-9860
University of California San Diego · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NEUROBIOLOGY TRAINING PROGRAMT32NS007220 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 1985 to 2023
$4.5M
GABAergic Neuron Differentiation in C.elegansR37NS035546 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 2017 to 2021
$2.4M
NIH HHS P40 OD010440NINDS NIH HHS R37 NS035546NINDS NIH HHS T32 NS007220
6 · The paper itself

Abstract

The translation initiation complex eIF3 imparts specialized functions to regulate protein expression. However, understanding of eIF3 activities in neurons remains limited despite widespread dysregulation of eIF3 subunits in neurological disorders. Here, we report a selective role of the

Indexed as

Protein BiosynthesisAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEukaryotic Initiation Factor-3NeuronsRNA, HelminthRNA, MessengerCaenorhabditis elegans ProteinsEukaryotic Initiation Factor-3RNA, HelminthRNA, Messenger5' utracetylcholine receptorC. elegansgeneticsgenomicsncs-2neuronal excitationseizuretranslation regulation

Identifiers

PMID34323215
PMCPMC8354637
OpenAlexW3185547771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.