ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2021
[Preparation and Evaluation of Hemoglobin-Bovine Serum Albumin Nanoparticles with Red Blood Cell Membrane Directional Coating].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Synergistic Therapy of Melanoma by Co-Delivery of Dacarbazine and Ferroptosis-Inducing Ursolic Acid Using Biomimetic Nanoparticles.ACS omega · 2024Article
- Emerging biomaterials for tumor immunotherapy.Biomaterials research · 2023Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo prepare hemoglobin-bovine serum albumin nanoparticles with red blood cell membrane directional coating (RBC-Hb/BSA-NP) and to evaluate their physicochemical properties and long circulation capability.
methodsThe bovine serum albumin nanoparticles modified with human hemoglobin (Hb/BSA-NP) were prepared by the solvent evaporation method. Then, the red blood cell (RBC) membrane was coated on the surface of Hb/BSA-NP by applying physical extrusion. The particle size, zeta potential and morphology of the resulting RBC-Hb/BSA-NP were characterized. The optimal amount of RBC membrane was determined by evaluating the integrity of the RBC membrane coating on RBC-Hb/BSA-NP, while the orientation of the RBC membrane was determined by measuring the content of sialic acid content on the surface of the RBC-Hb/BSA-NP. The anti-phagocytosis ability against macrophage of the RBC-Hb/BSA-NP was evaluated with fluorescence microscope and flow cytometry
resultsThe RBC-Hb/BSA-NP showed an average size of (127.7±3.5) nm, a zeta potential of (-17.1±0.28) mV, a clear core-shell structure and good stability within 72 h. The RBC membrane extracted from 0.8 mL of whole blood can completely coat 1 mL of Hb/BSA-NP (
conclusionRBC-Hb/BSA-NP was successfully constructed, and it was shown that the delivery system had prolonged circulation time.
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Registered trials
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