Trial reportInternational journal of colorectal disease2021
Prognostic nomogram to predict the overall survival of patients with early-onset colorectal cancer: a population-based analysis.
Trial report in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Establishment and validation of a prognostic nomogram for patients with early-onset stage I-II colon cancer.World journal of surgical oncology · 2023Trial
- Development and Validation of Platelet-Index Based Colorectal Cancer Survival Prognostic Nomogram.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- A predictive nomogram for predicting liver metastasis in early-onset colon cancer: a population-based study.Translational cancer research · 2025Article
- Article
- Establishment and Validation of a Prognostic Nomogram for Predicting Postoperative Overall Survival in Advanced Stage III-IV Colorectal Cancer Patients.Cancer medicine · 2024Article
- Article
- Construction and validation of a nomogram for predicting disease-free survival after radical resection of rectal cancer using perioperative inflammatory indicators.Journal of gastrointestinal oncology · 2024Article
- Developing a Nomogram for Predicting Colorectal Cancer and Its Precancerous Lesions Based on Data from Three Non-Invasive Screening Tools, APCS, FIT, and sDNA.Journal of multidisciplinary healthcare · 2024Article
- Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early-onset colorectal cancer.Frontiers in oncology · 2024Article
- Advantage of log odds of positive lymph nodes in prognostic evaluation of patients with early-onset colon cancer.World journal of gastrointestinal surgery · 2023Article
- Log odds of positive lymph nodes show better predictive performance on the prognosis of early-onset colorectal cancer.International journal of colorectal disease · 2023Article
- Construction and validation of a nomogram model for predicting the overall survival of colorectal cancer patients.BMC surgery · 2023Article
- Construction and validation of a nomogram of risk factors and cancer-specific survival prognosis for combined lymphatic metastases in patients with early-onset colorectal cancer.International journal of colorectal disease · 2023Article
- Prediction models for overall and cancer-specific survival in patients with metastatic early-onset colorectal cancer: a population-based study.International journal of colorectal disease · 2023Article
- CD39-Expressing CD8Cancers · 2023Article
- Causes of death among early-onset colorectal cancer population in the United States: a large population-based study.Frontiers in oncology · 2023Article
- Early-onset locally advanced rectal cancer characteristics, a practical nomogram and risk stratification system: a population-based study.Frontiers in oncology · 2023Article
- Nomograms predicting cancer-specific survival for stage IV colorectal cancer with synchronous lung metastases.Scientific reports · 2022Article
- Nomogram predicting the cancer-specific survival of early-onset colorectal cancer patients with synchronous liver metastasis: a population-based study.International journal of colorectal disease · 2022Article
- FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma.Aging · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
purposeThe present study aimed to identify independent clinicopathological and socio-economic prognostic factors associated with overall survival of early-onset colorectal cancer (EO-CRC) patients and then establish and validate a prognostic nomogram for patients with EO-CRC.
methodsEligible patients with EO-CRC diagnosed from 2010 to 2017 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into a training cohort and a testing cohort. Independent prognostic factors were obtained using univariate and multivariate Cox analyses and were used to establish a nomogram for predicting 3- and 5-year overall survival (OS). The discriminative ability and calibration of the nomogram were assessed using C-index values, AUC values, and calibration plots.
resultsIn total, 5585 patients with EO-CRC were involved in the study. Based on the univariate and multivariate analyses, 15 independent prognostic factors were assembled into the nomogram to predict 3- and 5-year OS. The nomogram showed favorable discriminatory ability as indicated by the C-index (0.840, 95% CI 0.827-0.850), and the 3- and 5-year AUC values (0.868 and 0.84869 respectively). Calibration plots indicated optimal agreement between the nomogram-predicted survival and the actual observed survival. The results remained reproducible in the testing cohort. The C-index of the nomogram was higher than that of the TNM staging system (0.840 vs 0.804, P < 0.001).
conclusionA novel prognostic nomogram for EO-CRC patients based on independent clinicopathological and socio-economic factors was developed, which was superior to the TNM staging system. The nomogram could facilitate postoperative individual prognosis prediction and clinical decision-making.
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