ReviewVirchows Archiv : an international journal of pathology2022
Spindle cell lesions of the breast: a diagnostic approach.
Review in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Primary breast leiomyosarcoma-pathological challenges and immunohistochemical insights into the diagnosis of a rare tumor: a case report.Ewha medical journal · 2026Article
- Spindle Cell Fibromatosis of the Breast: A Lesson in Malignancy Mimicry.Clinical case reports · 2026Article
- The promise of artificial intelligence in diagnostic breast pathology.Virchows Archiv : an international journal of pathology · 2026Article
- Nodular Fasciitis in Breast in an Elderly Woman With a Giant Mass: A Case Report.Clinical case reports · 2026Article
- Genomic Landscape and Therapeutic Implications of Metaplastic Breast Carcinoma: Insights from a Nationwide Database Including Diagnostic Mimickers.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Case Report: Fibromatosis-like metaplastic breast cancer: a case with detection of three genetic alterations, accompanied by local recurrence, lymph node metastasis, and distant metastasis.Frontiers in oncology · 2026Article
- Case Report: Spindle cell metaplastic breast carcinoma.Frontiers in oncology · 2026Article
- A Rare Tumor in a Septuagenarian Female 16 Years After Radical Mastectomy for Breast Carcinoma.Clinical case reports · 2025Article
- Mystifying Fibroepithelial Stromal Polyps of the Breast Nipple: A Report of Three Rare Cases and a Literature Review.Cureus · 2025Article
- Schwannoma in the lower inner quadrant of the right breast in a male patient: A rare case report.Medicine · 2025Article
- Fibromatosis-like metaplastic carcinoma with aggressive metastasis and a TERT promoter mutation: a case report and literature review.Frontiers in medicine · 2025Article
- Desmoid-type fibromatosis of the breast: a case report and literature review.Frontiers in oncology · 2025Article
- Article
- Molecular pathology in breast disease: diagnostic, prognostic, and therapeutic tools.Virchows Archiv : an international journal of pathology · 2024Review
- Desmoid-type fibromatosis of the breast in a male patient following cosmetic surgery: a rare case report.Frontiers in oncology · 2024Article
- Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent.Nature communications · 2023Article
- Clinical perspectives and outcomes of the giant breast phyllodes tumor and sarcoma: a real-world retrospective study.BMC cancer · 2023Article
- Fibromatosis-like metaplastic carcinoma of the breast: Two case reports.World journal of clinical cases · 2023Article
- Mammary myofibroblastoma: Presentation of case.International journal of surgery case reports · 2023Article
- Next-generation sequencing in breast pathology: real impact on routine practice over a decade since its introduction.Histopathology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
Abstract
Spindle cell lesions of the breast comprise a heterogeneous group of lesions, ranging from reactive and benign processes to aggressive malignant tumours. Despite their rarity, they attract the attention of breast pathologists due to their overlapping morphological features and diagnostic challenges, particularly on core needle biopsy (CNB) specimens. Pathologists should recognise the wide range of differential diagnoses and be familiar with the diverse morphological appearances of these lesions to make an accurate diagnosis and to suggest proper management of the patients. Clinical history, immunohistochemistry, and molecular assays are helpful in making a correct diagnosis in morphologically challenging cases. In this review, we present our approach for the diagnosis of breast spindle cell lesions, highlighting the main features of each entity and the potential pitfalls, particularly on CNB. Breast spindle cell lesions are generally classified into two main categories: bland-appearing and malignant-appearing lesions. Each category includes a distinct list of differential diagnoses and a panel of immunohistochemical markers. In bland-appearing lesions, it is important to distinguish fibromatosis-like spindle cell metaplastic breast carcinoma from other benign entities and to distinguish fibromatosis from scar tissue. The malignant-appearing category includes spindle cell metaplastic carcinoma, stroma rich malignant phyllodes tumour, other primary and metastatic malignant spindle cell tumours of the breast, including angiosarcoma and melanoma, and benign mimics such as florid granulation tissue and nodular fasciitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.