ArticleRice (New York, N.Y.)2021
Comparisons within the Rice GA 2-Oxidase Gene Family Revealed Three Dominant Paralogs and a Functional Attenuated Gene that Led to the Identification of Four Amino Acid Variants Associated with GA Deactivation Capability.
Article in Rice (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- Maize ZmMYB59 inhibits post-germinative shoot and root elongation through ZmGA2ox3/10-mediated gibberellin catabolism.The New phytologist · 2026Article
- Allelic expression and subgenome bias influence plant height in cultivated hybrid sugarcane.aBIOTECH · 2026Article
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- Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits.Journal of advanced research · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- The identification of gibberellin 2-oxidase gene family in cotton and functional analysis.BMC plant biology · 2026Article
- Systematic mutagenesis reveals dominant-minor paralog configurations in the riceFrontiers in plant science · 2026Article
- Facilitating Phloem-Mediated Iron Transport Can Improve the Adaptation of Rice Seedlings to Iron Deficiency Stress.Rice (New York, N.Y.) · 2025Article
- Diversity of Gibberellin 2-oxidase genes in the barley genome offers opportunities for genetic improvement.Journal of advanced research · 2024Article
- Jasmonate-mediated gibberellin catabolism constrains growth during herbivore attack in rice.The Plant cell · 2023Article
- Two genomic regions of a sodium azide induced rice mutant confer broad-spectrum and durable resistance to blast disease.Rice (New York, N.Y.) · 2022Article
- Genome-wide association study reveals novel QTLs and candidate genes for seed vigor in rice.Frontiers in plant science · 2022Article
- A VIN3-like Protein OsVIL1 Is Involved in Grain Yield and Biomass in Rice.Plants (Basel, Switzerland) · 2021Article
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11 authors at 2 institutions in 1 country.
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Abstract
backgroundGA 2-oxidases (GA2oxs) are involved in regulating GA homeostasis in plants by inactivating bioactive GAs through 2β-hydroxylation. Rice GA2oxs are encoded by a family of 10 genes; some of them have been characterized, but no comprehensive comparisons for all these genes have been conducted.
resultsRice plants with nine functional GA2oxs were demonstrated in the present study, and these genes not only were differentially expressed but also revealed various capabilities for GA deactivation based on their height-reducing effects in transgenic plants. Compared to that of wild-type plants, the relative plant height (RPH) of transgenic plants was scored to estimate their reducing effects, and 8.3% to 59.5% RPH was observed. Phylogenetic analysis of class I GA2ox genes revealed two functionally distinct clades in the Poaceae. The OsGA2ox3, 4, and 8 genes belonging to clade A showed the most severe effect (8.3% to 8.7% RPH) on plant height reduction, whereas the OsGA2ox7 gene belonging to clade B showed the least severe effect (59.5% RPH). The clade A OsGA2ox3 gene contained two conserved C186/C194 amino acids that were crucial for enzymatic activity. In the present study, these amino acids were replaced with OsGA2ox7-conserved arginine (C186R) and proline (C194P), respectively, or simultaneously (C186R/C194P) to demonstrate their importance in planta. Another two amino acids, Q220 and Y274, conserved in OsGA2ox3 were substituted with glutamic acid (E) and phenylalanine (F), respectively, or simultaneously to show their significance in planta. In addition, through sequence divergence, RNA expression profile and GA deactivation capability analyses, we proposed that OsGA2ox1, OsGA2ox3 and OsGA2ox6 function as the predominant paralogs in each of their respective classes.
conclusionsThis study demonstrates rice has nine functional GA2oxs and the class I GA2ox genes are divided into two functionally distinct clades. Among them, the OsGA2ox7 of clade B is a functional attenuated gene and the OsGA2ox1, OsGA2ox3 and OsGA2ox6 are the three predominant paralogs in the family.
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