Evidence map›Paper›PMID 34322723›Full record

ArticleExperimental brain research2021

Ibuprofen does not inhibit RhoA-mediated growth cone collapse of embryonic chicken retinal axons by LPA.

James Vinton, Adaeze Aninweze, Eric Birgbauer

Abstract read
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In one paragraph

Article in Experimental brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James Vinton *Department of Biology, Winthrop University, Rock Hill, SC, 29733, USA.
Adaeze AninwezeDepartment of Biology, Winthrop University, Rock Hill, SC, 29733, USA.
Eric BirgbauerDepartment of Biology, Winthrop University, Rock Hill, SC, 29733, USA. birgbauere@winthrop.edu.ORCID http://orcid.org/0000-0002-5555-4970
Winthrop University · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
DEVELOPMENT OF ANISOTROPIC VISUAL SENSITIVITYR01EY002445 · NEI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MAYER, MELANIE L · 1985 to 1985
–
National Eye Institute REY024453ANational Institute of General Medical Sciences P20GM103499NEI NIH HHS REY024453ANIGMS NIH HHS P20GM103499
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that causes neuronal growth cones to collapse and neurites to retract through a RhoA-ROCK mediated pathway. It has been reported that the NSAID ibuprofen improves regeneration after spinal cord injury through a mechanism of inhibiting RhoA. This leads to the hypothesis that ibuprofen should block LPA-mediated growth cone collapse. We tested this hypothesis by treating embryonic chick retinal neurons with ibuprofen followed by LPA. Retinal growth cones collapsed with LPA in the presence of ibuprofen similar to control; however, growth cone collapse was effectively blocked by a ROCK inhibitor. Thus, our results do not support the designation of ibuprofen as a direct RhoA inhibitor.

Indexed as

ChickensGrowth ConesAnimalsAxonsCells, CulturedChick EmbryoIbuprofenLysophospholipidsIbuprofenlysophosphatidic acidLysophospholipidsGrowth coneIbuprofenLysophosphatidic acidRetinal ganglion cellsRhoA

Identifiers

PMID34322723
OpenAlexW3185174545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.