ArticleCerebral cortex (New York, N.Y. : 1991)2022
Differential Role for Hippocampal Subfields in Alzheimer's Disease Progression Revealed with Deep Learning.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Convolutional neural network models of structural MRI for discriminating categories of cognitive impairment: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Surface expansion regionalization of the hippocampus in early brain development.Developmental cognitive neuroscience · 2026Article
- Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.Brain sciences · 2025Article
- A mini review of transforming dementia care in China with data-driven insights: overcoming diagnostic and time-delayed barriers.Frontiers in aging neuroscience · 2025Review
- CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer's disease spectrum.Brain communications · 2025Article
- Fractional gradient optimized explainable convolutional neural network for Alzheimer's disease diagnosis.Heliyon · 2024Article
- DSnet: a new dual-branch network for hippocampus subfield segmentation.Scientific reports · 2024Article
- Estimating individual trajectories of structural and cognitive decline in mild cognitive impairment for early prediction of progression to dementia of the Alzheimer's type.Scientific reports · 2024Article
- Article
- fMRI-based Alzheimer's disease detection via functional connectivity analysis: a systematic review.PeerJ. Computer science · 2024Article
- Correlation studies of Hippocampal Morphometry and Plasma NFL Levels in Cognitively Unimpaired Subjects.IEEE transactions on computational social systems · 2023Article
- Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects.Frontiers in aging neuroscience · 2023Article
- Identifying the regional substrates predictive of Alzheimer's disease progression through a convolutional neural network model and occlusion.Human brain mapping · 2022Article
- Early-Stage Alzheimer's Disease Categorization Using PET Neuroimaging Modality and Convolutional Neural Networks in the 2D and 3D Domains.Sensors (Basel, Switzerland) · 2022Article
- Model-based stratification of progression along the Alzheimer disease continuum highlights the centrality of biomarker synergies.Alzheimer's research & therapy · 2022Article
- A novel cascade machine learning pipeline for Alzheimer's disease identification and prediction.Frontiers in aging neuroscience · 2022Article
- Subtyping of mild cognitive impairment using a deep learning model based on brain atrophy patterns.Cell reports. Medicine · 2021Article
- Deep learning interpretability in neuroimaging: A comprehensive survey and methodological recommendations.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Mild cognitive impairment (MCI) is often considered the precursor of Alzheimer's disease. However, MCI is associated with substantially variable progression rates, which are not well understood. Attempts to identify the mechanisms that underlie MCI progression have often focused on the hippocampus but have mostly overlooked its intricate structure and subdivisions. Here, we utilized deep learning to delineate the contribution of hippocampal subfields to MCI progression. We propose a dense convolutional neural network architecture that differentiates stable and progressive MCI based on hippocampal morphometry with an accuracy of 75.85%. A novel implementation of occlusion analysis revealed marked differences in the contribution of hippocampal subfields to the performance of the model, with presubiculum, CA1, subiculum, and molecular layer showing the most central role. Moreover, the analysis reveals that 10.5% of the volume of the hippocampus was redundant in the differentiation between stable and progressive MCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.