Evidence map›Paper›PMID 34322663›Full record

ArticleCancer drug resistance (Alhambra, Calif.)2019

Drug resistance and combating drug resistance in cancer.

Xuan Wang, Haiyun Zhang, Xiaozhuo Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer drug resistance (Alhambra, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 627 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
627citing papers in PubMed, 3 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

627 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,058 citations in OpenAlex.

  1. Pooled it
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  4. Mechanisms of chemoresistance in gastric cancer: interplay between microRNAs and the tumor microenvironment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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567 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xuan WangDepartment of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Haiyun ZhangDepartment of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Xiaozhuo ChenDepartment of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Ohio University · US

Funding

Extracellular ATP in cancer: mechanism study of ATP internalization and ATP-induced drug resistance in cancer cells and tumorsR15CA242177 · NCI · OHIO UNIVERSITY ATHENS · PI CHEN, XIAOZHUO · 2019 to 2019
$450k
NCI NIH HHS R15 CA242177
6 · The paper itself

Abstract

Cancer is the second leading cause of death in the US. Current major treatments for cancer management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy. Despite the endeavors and achievements made in treating cancers during the past decades, resistance to classical chemotherapeutic agents and/or novel targeted drugs continues to be a major problem in cancer therapies. Drug resistance, either existing before treatment (intrinsic) or generated after therapy (acquired), is responsible for most relapses of cancer, one of the major causes of death of the disease. Heterogeneity among patients and tumors, and the versatility of cancer to circumvent therapies make drug resistance more challenging to deal with. Better understanding the mechanisms of drug resistance is required to provide guidance to future cancer treatment and achieve better outcomes. In this review, intrinsic and acquired resistance will be discussed. In addition, new discoveries in mechanisms of drug resistance will be reviewed. Particularly, we will highlight roles of ATP in drug resistance by discussing recent findings of exceptionally high levels of intratumoral extracellular ATP as well as intracellular ATP internalized from extracellular environment. The complexity of drug resistance development suggests that combinational and personalized therapies, which should take ATP into consideration, might provide better strategies and improved efficacy for fighting drug resistance in cancer.

Indexed as

ATP binding cassette transportersCancer stem cellsepigeneticsepithelial mesenchymal transitionextracellular ATPmacropinocytosismicroRNA

Identifiers

PMID34322663
PMCPMC8315569
OpenAlexW2938150871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.