ArticleJournal of patient-centered research and reviews2021
The Experience of OFF Periods in Parkinson's Disease: Descriptions, Triggers, and Alleviating Factors.
Article in Journal of patient-centered research and reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Safety of Immersive Virtual Reality for the Management of Parkinson's Disease.Sensors (Basel, Switzerland) · 2024Trial
- Inhaled Levodopa for the Management of OFF Episodes in Parkinson's Disease: A Cost-Effectiveness Analysis.PharmacoEconomics · 2026Article
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Compliance and Satisfaction for 16 months of Adapted Tango vs. Supervised Walking for People with Parkinson's.NPJ Parkinson's disease · 2025Article
- The ketogenic diet in Parkinson's disease: a potential therapeutic strategy.Pharmacological reports : PR · 2025Review
- Three Months of Partnered Dance Aerobic Exercise Can Reduce OFF-time and Enhance Quality of Life in Older Adults with Parkinson's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Determinants of Adherence and Satisfaction in Parkinson's Disease Exercise Programs: A Comparison of 16-Months of Adapted Tango vs. Supervised Walking.Research square · 2025Article
- Dual stream transformer for medication state classification in Parkinson's disease patients using facial videos.NPJ digital medicine · 2025Article
- Optimized use of safinamide as an add-on therapy in Asian patients with Parkinson's disease: a narrative review and expert opinion.Therapeutic advances in neurological disorders · 2025Review
- Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders.Pharmaceutical research · 2024Review
- A Qualitative Study on Perspectives of Parkinson's Disease Medications: Insights from Patient Focus Groups.Patient preference and adherence · 2024Article
- Real-World Experiences of Parkinson's Disease OFF Time and Role of Demographics.Journal of patient-centered research and reviews · 2024Article
- Analytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson's disease in Japan.Scientific reports · 2023Article
- The Weight of a Word.Journal of patient-centered research and reviews · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWearing off of Parkinson's disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We aimed to assess the lived experience of OFF periods for people with Parkinson's disease.
methodsParticipants in the longitudinal Fox Insight study who endorsed OFF periods were invited to complete a survey consisting of both multiple-choice and free-text responses. Descriptive statistics were used to summarize multiple-choice responses, and free-text responses were classified into themes through iterative discussion by 3 movement disorders specialists.
resultsA total of 2110 participants (52.4% male) completed the survey. Tremor was the most common description of OFF periods (n=1038, 49.2%), followed by gait changes (n=535, 25.4%) and rigidity (n=430, 20.4%). Of 1498 specific triggers for OFF symptoms, the most common was stress (n=920, 61.4%), followed by anxiety/depression (n=476, 31.8%) and tiredness/fatigue (n=351, 23.4%). Common coping strategies (n=1416 responses) included exercise (n=678, 47.9%), taking a break (n=504, 35.6%), and meditation (n=276, 19.5%).
conclusionsAlthough OFF periods are common, the individual experiences of OFF vary. This knowledge could be used to develop new counseling strategies for OFF periods in people with Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.