Evidence map›Paper›PMID 34322507›Full record

ReviewFrontiers in nutrition2021

Dairy-Derived and Egg White Proteins in Enhancing Immune System Against COVID-19.

Gaber El-Saber Batiha, Mohammed Alqarni, Dina A B Awad, Abdelazeem M Algammal, Richard Nyamota, Mir I I Wahed, Muhammad Ajmal Shah, Mohammad N Amin, Babatunde O Adetuyi, Helal F Hetta and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 43 citations in OpenAlex.

  1. Immunomodulatory Effects ofAntioxidants (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 16 institutions in 12 countries.

Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Mohammed AlqarniDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Dina A B AwadDepartment of Food Hygiene, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Abdelazeem M AlgammalDepartment of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
Richard NyamotaDepartment of Biochemistry and Molecular Biology, Faculty of Science, Egerton University, Njoro, Kenya.
Mir I I WahedDepartment of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.
Muhammad Ajmal ShahDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Mohammad N AminDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
Babatunde O AdetuyiDepartment of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Nigeria.
Helal F HettaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Asyut, Egypt.
Natália Cruz-MartinsFaculty of Medicine, University of Porto, Porto, Portugal.
Niranjan KoiralaDepartment of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu, Nepal.
Arabinda GhoshMicrobiology Division, Department of Botany, Gauhati University, Guwahati, India.
Javier EcheverríaDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Jorge Pamplona PagnossaBiological Sciences Department, Federal University of Lavras (UFLA), Lavras, Brazil.
Jean-Marc SabatierUniversité Aix-Marseille, Institut de Neuro-Physiopathologie (INP), UMR 7051, Faculté de Pharmacie, Marseille, France.
Assiut University · EGAtish Dipankar University of Science and Technology · BDBenha University · EGB.P. Koirala Institute of Health Sciences · NPDamanhour University · EGEgerton University · KEGauhati University · INGovernment College University, Faisalabad · PKInstitut de Neurophysiopathologie · FRPrecious Cornerstone UniversitySuez Canal University · EGTaif University · SAUniversidad de Santiago de Chile · CLUniversidade do Porto · PTUniversidade Federal de Lavras · BRUniversity of Rajshahi · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease (COVID-19) is a global health challenge, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) triggers a plethora of respiratory disturbances and even multiple organs failure that can be fatal. Nutritional intervention is one of the key components toward to a proper management of COVID-19 patients, especially in those requiring medication, and should thus be considered the first-line treatment. Immuno-modulation and -stimulation are currently being explored in COVID-19 management and are gaining interest by food and pharmaceutical industries. Various dietary combinations, bioactive components, nutrients and fortified foods have been reported to modulate inflammation during disease progression. Dietary combinations of dairy-derived products and eggs are gaining an increasing attention given the huge immunomodulatory and anti-inflammatory properties attributed to some of their chemical constituents. Eggs are complex dietary components containing many essential nutrients and bioactive compounds as well as a high-quality proteins. Similarly, yogurts can replenish beneficial bacteria and contains macronutrients capable of stimulating immunity by enhancing cell immunity, reducing oxidative stress, neutralizing inflammation and regulating the intestinal barriers and gut microbiome. Thus, this review highlights the impact of nutritional intervention on COVID-19 management, focusing on the immunomodulatory and inflammatory effects of immune-enhancing nutrients.

Indexed as

coronavirus disease 2019immunomodulationnutrientsnutritional therapySARS-CoV-2

Identifiers

PMID34322507
PMCPMC8310913
OpenAlexW3182332975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.