SynthesisFrontiers in oncology2021
Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Accumulating evidence from meta-analyses of prognostic studies on oral cancer: towards biomarker-driven patient selection.BMC cancer · 2024Pooled it
- Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.Head & neck · 2022Pooled it
- The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Anti-lipid peroxidation attenuates Schwann cell repair phenotype and attenuates PNI-like behavior in oral squamous cell carcinoma.Translational cancer research · 2026Article
- Neuroimmunology of Oral Cancer: Tumor Progression, Systemic Inflammation, and Neural Circuit Dysfunction from the Cerebellum to the Frontal Cortex.Molecular biology reports · 2026Review
- Outcomes of patients with oral cavity squamous cell carcinomas with perineural invasion treated with adjuvant intensity modulated radiation therapy (IMRT).Clinical and translational radiation oncology · 2026Article
- Prognostic factors and cervical lymph node management in tongue squamous cell carcinoma: a retrospective cohort study.Clinical oral investigations · 2026Article
- Dual Immunohistochemistry Enhances Detection of Perineural Invasion in Oral Squamous Cell Carcinoma.Oral diseases · 2026Article
- Impact of Depth of Invasion in Node-Negative Oral Tongue Cancer Treated With Surgery Alone.The Kaohsiung journal of medical sciences · 2026Article
- Pattern of Mandibular Bone Invasion as a Prognostic Factor.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Long-term oncologic outcomes and prognostic factors related to recurrences in pathologic Stage I/II early oral tongue cancer.Frontiers in surgery · 2025Article
- Is Perineural Invasion an Independent Prognostic Factor for Local Recurrence in Oral Squamous Cell Carcinoma?Journal of maxillofacial and oral surgery · 2024Article
- Review
- Perineural invasion in incisional biopsy is an indication for in-continuity resection in oral squamous cell carcinoma of the tongue and floor of the mouth.Oral and maxillofacial surgery · 2024Article
- Opioids and Cancer: Current Understanding and Clinical Considerations.Current oncology (Toronto, Ont.) · 2024Review
- Understanding the role of nerves in head and neck cancers - a review.Oncology reviews · 2024Review
- Perineural Invasion Is a Significant Prognostic Factor in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Subcategorization of Perineural Invasion and Its Impact on Survival in Patients with Oral Squamous Cell Carcinoma.Head and neck pathology · 2023Article
- Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI. MATERIALS AND
methodsPubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. The primary outcomes were the hazard ratio (HR) for locoregional recurrence, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The random-effect model was used in all analyses.
resultsSeventeen studies (4445 patients) were included. Using adjusted HRs, the presence of PNI was associated with a higher risk of locoregional recurrence (HR=1.73, 95%CI: 1.07-2.79, P=0.025, I
conclusionThe presence of PNI significantly affects the locoregional recurrence and survival outcomes among patients with OTSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.