Evidence map›Paper›PMID 34322088›Full record

ArticleFrontiers in neurology2021

Neuromuscular and Neuroendocrinological Features Associated With

Gianluca Piccolo, Giuseppe d'Annunzio, Elisabetta Amadori, Antonella Riva, Paola Borgia, Domenico Tortora, Mohamad Maghnie, Carlo Minetti, Eloisa Gitto, Michele Iacomino and 5 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Case Report: A novel missense variant inFrontiers in pediatrics · 2025
    Article
  5. Wieacker-Wolff syndrome with hyperinsulinemic hypoglycemia successfully treated using diazoxide: A case report.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2025
    Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Gianluca PiccoloPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Giuseppe d'AnnunzioPediatric Clinic and Endocrinology, Regional Center for Pediatric Diabetes, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Elisabetta AmadoriPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Antonella RivaDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Paola BorgiaDepartment of Pediatrics, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy.
Domenico TortoraNeuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Mohamad MaghnieDepartment of Pediatrics, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy.
Carlo MinettiPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Eloisa GittoDepartment of Human Pathology of the Adult and Developmental Age, "Gaetano Barresi" University of Messina, Messina, Italy.
Michele IacominoUnit of Medical Genetics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Simona BaldassariUnit of Medical Genetics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Chiara FiorilloPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Federico ZaraDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Pasquale StrianoPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Vincenzo SalpietroPediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Istituto Giannina Gaslini · ITUniversity of Genoa · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wieacker-Wolff syndrome (WWS) is an X-linked Arthrogryposis Multiplex Congenita (AMC) disorder associated with broad neurodevelopmental impairment. The genetic basis of WWS lies in hemizygous pathogenic variants in

Indexed as

arthrogryposiscase reportexome sequencingneurodevelopmental disordersneuromuscular junctionrecurrent hypoglycemic eventsWieacker-Wolff syndromeZC4H2

Identifiers

PMID34322088
PMCPMC8313121
OpenAlexW3181815680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.