Evidence map›Paper›PMID 34322022›Full record

ArticleFrontiers in pharmacology2021

Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing

Juan A Rubiolo, Emilio Lence, Concepción González-Bello, María Roel, José Gil-Longo, Manuel Campos-Toimil, Eva Ternon, Olivier P Thomas, Antonio González-Cantalapiedra, Henar López-Alonso and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Vasorelaxant and Hypotensive Mechanisms ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Juan A RubioloDepartamento de Zoología, Genética y Antropología Física, Universidad de Santiago de Compostela, Lugo, Spain.
Emilio LenceCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Concepción González-BelloCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
María RoelDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.
José Gil-LongoDepartamento de Farmacología, Facultad de Farmacia, Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Manuel Campos-ToimilDepartamento de Farmacología, Facultad de Farmacia, Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Eva TernonCNRS, OCA, IRD, Géoazur, Université Côte d'Azur, Valbonne, France.
Olivier P ThomasMarine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, Galway, Ireland.
Antonio González-CantalapiedraDepartamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Hospital Veterinario Universitario Rof Codina, Facultad de Veterinaria, Universidad de Santiago de Compostel, Lugo, Spain.
Henar López-AlonsoDepartamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Hospital Veterinario Universitario Rof Codina, Facultad de Veterinaria, Universidad de Santiago de Compostel, Lugo, Spain.
Mercedes R VieytesDepartamento de Fisiología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.
Luis M BotanaDepartamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.
Universidade de Santiago de Compostela · ESCenter for Research in Molecular Medicine and Chronic Diseases · ESMinisterio de Ciencia y Tecnología · AROllscoil na Gaillimhe – University of Galway · IEUniversité Côte d'Azur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crambescins are guanidine alkaloids from the sponge

Indexed as

crambescindockingHepG2 cellshypotensionmetallothioneinmolecular dynamics simulationsnitric oxide synthase

Identifiers

PMID34322022
PMCPMC8312399
OpenAlexW3181856829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.