Evidence map›Paper›PMID 34322004›Full record

ArticleFrontiers in human neuroscience2021

Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System.

Kristin K Sellers, Ro'ee Gilron, Juan Anso, Kenneth H Louie, Prasad R Shirvalkar, Edward F Chang, Simon J Little, Philip A Starr

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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  11. Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Review
  13. Building and Sustaining Open-Source Medical Device Projects.IEEE transactions on bio-medical engineering · 2025
    Review
  14. High Beta Power in the Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristin K SellersDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Ro'ee GilronDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Juan AnsoDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Kenneth H LouieDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Prasad R ShirvalkarDepartment of Anesthesiology (Pain Management), Neurology, and Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Simon J LittleDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United States.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.

Funding

Multisite adaptive brain stimulation for multidimensional treatment of refractory chronic painUH3NS115631 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHIRVALKAR, PRASAD · 2019 to 2023
$6.9M
Accelerating Dissemination of Implantable Neurotechnology for Clinical ResearchU24NS113637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORTON, DAVID ALLENSON, DENISON, TIMOTHY · 2020 to 2024
$4.4M
Closed Loop Deep Brain Stimulation for Parkinson's DiseaseUH3NS100544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2016 to 2022
$4.1M
Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
NINDS NIH HHS K23 NS120037NINDS NIH HHS U24 NS113637NINDS NIH HHS UH3 NS100544NINDS NIH HHS UH3 NS115631
6 · The paper itself

Abstract

Closed-loop neurostimulation is a promising therapy being tested and clinically implemented in a growing number of neurological and psychiatric indications. This therapy is enabled by chronically implanted, bidirectional devices including the Medtronic Summit RC+S system. In order to successfully optimize therapy for patients implanted with these devices, analyses must be conducted offline on the recorded neural data, in order to inform optimal sense and stimulation parameters. The file format, volume, and complexity of raw data from these devices necessitate conversion, parsing, and time reconstruction ahead of time-frequency analyses and modeling common to standard neuroscientific analyses. Here, we provide an open-source toolbox written in Matlab which takes raw files from the Summit RC+S and transforms these data into a standardized format amenable to conventional analyses. Furthermore, we provide a plotting tool which can aid in the visualization of multiple data streams and sense, stimulation, and therapy settings. Finally, we describe an analysis module which replicates RC+S on-board power computations, a functionality which can accelerate biomarker discovery. This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses.

Indexed as

adaptive stimulationbidirectional deviceclosed-loop stimulationDBSopen-source softwareSummit RC+S

Identifiers

PMID34322004
PMCPMC8312257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.