Evidence map›Paper›PMID 34321955›Full record

ReviewJournal of carcinogenesis2021

Lipid metabolism in cancer: A systematic review.

Wafa Khan, Dominic Augustine, Roopa S Rao, Shankargouda Patil, Kamran Habib Awan, Samudrala Venkatesiah Sowmya, Vanishri C Haragannavar, Kavitha Prasad

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of carcinogenesis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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  14. Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Wafa KhanDepartment of Oral Pathology and Microbiology, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Dominic AugustineDepartment of Oral Pathology and Microbiology, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Roopa S RaoDepartment of Oral Pathology and Microbiology, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Kamran Habib AwanCollege of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah, United States.
Samudrala Venkatesiah SowmyaDepartment of Oral Pathology and Microbiology, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Vanishri C HaragannavarDepartment of Oral Pathology and Microbiology, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Kavitha PrasadDepartment of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
M S Ramaiah University of Applied Sciences · INJazan University · SARoseman University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical studies and clinical trials have emphasized the decisive role of lipid metabolism in tumor proliferation and metastasis. This systematic review aimed to explore the existing literature to evaluate the role and significance of the genes and pathways most commonly involved in the regulation of lipid metabolism in cancer. The literature search was performed as per Preferred Reporting Items for Systematic Reviews and Meta-analyses. Approximately 2396 research articles were initially selected, of which 215 were identified as potentially relevant for abstract review. Upon further scrutiny, 62 of the 215 studies were reviews, seminars, or presentations, and 44 were original study articles and were thus included in the systematic review. The predominant gene involved in lipid metabolism in cancer was stearoyl-coenzyme A desaturase 1 (SCD1), followed by fatty acid synthase (FASN). The pathway most commonly involved in lipid metabolism in cancer was the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, followed by the mitogen activated protein kinase (MAPK) pathway. SCD1 and FASN play significant roles in the initiation and progression of cancer and represent attractive targets for potentially effective anti-cancer treatment strategies. The regulation of cancer metabolism by the Akt kinases will be an interesting topic of future study.

Indexed as

Aktfatty acid synthaselipid metabolismoral cancerPI3Ksignaling pathwaysstearoyl-coenzyme A desaturase

Identifiers

PMID34321955
PMCPMC8312377
OpenAlexW3157190375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.