Evidence map›Paper›PMID 34321855›Full record

SynthesisWorld journal of gastroenterology2021

Endoscopic submucosal dissection

Xiong Chang Lim, Kameswara Rishi Yeshayahu Nistala, Cheng Han Ng, Snow Yunni Lin, Darren Jun Hao Tan, Khek-Yu Ho, Choon-Seng Chong, Mark Muthiah

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Endoscopic Submucosal Dissection Versus Surgery or Endoscopic Mucosal Resection for Metachronous Early Gastric Cancer: a Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Review
  9. Large colorectal lesions: Expanding the boundaries of endoscopic management.World journal of gastrointestinal endoscopy · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Percutaneous needle decompression for tension pneumoperitoneum during GI endoscopy: a step-by-step guide.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025
    Review
  18. Review
  19. Endoscopic approaches to the management of dysplasia in inflammatory bowel disease: A state-of-the-art narrative review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiong Chang LimYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Kameswara Rishi Yeshayahu NistalaYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Cheng Han NgYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Snow Yunni LinYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Darren Jun Hao TanYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Khek-Yu HoDepartment of Medicine, National University Hospital, Singapore 119074, Singapore.
Choon-Seng ChongDepartment of Surgery, National University Hospital, Singapore 119074, Singapore.
Mark MuthiahDepartment of Medicine, National University Hospital, Singapore 119074, Singapore. mdcmdm@nus.edu.sg.
National University of Singapore · SGNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic submucosal dissection (ESD) has shown to be effective in management of colorectal neoplasm in the Asian countries, while its implementation in Western countries where endoscopic mucosal resection (EMR) is preferred is still debatable.

aimTo compare the surgical, histological, and oncological outcomes between ESD and EMR in the treatment of colorectal polyps, with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.

methodsEmbase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing

resultsOf 281344 colorectal polyps from 21 studies were included. When compared to EMR, the pooled analysis revealed ESD was associated with higher

conclusionESD resulted in better resection outcomes and lower recurrence compared to EMR. With appropriate training, ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps, without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion.

Indexed as

Colonic PolypsColorectal NeoplasmsEndoscopic Mucosal ResectionAsiaHumansIntestinal MucosaJapanNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeColonic polypsColonoscopyColorectal neoplasmEndoscopic mucosal resectionEndoscopy

Identifiers

PMID34321855
PMCPMC8291020
OpenAlexW3187072082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.