Evidence map›Paper›PMID 34321844›Full record

ReviewWorld journal of gastroenterology2021

Human immune repertoire in hepatitis B virus infection.

Qiao Zhan, Jing-Hang Xu, Yan-Yan Yu, Emily Lo Kk, Felicianna, Hani El-Nezami, Zheng Zeng

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Qiao ZhanDepartment of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
Jing-Hang XuDepartment of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
Yan-Yan YuDepartment of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
Emily Lo KkSchool of Biological Sciences, University of Hong Kong, Hong Kong, China.
Felicianna
Hani El-NezamiSchool of Biological Sciences, University of Hong Kong, Hong Kong, China.
Zheng ZengDepartment of Infectious Diseases, Peking University First Hospital, Beijing 100034, China. zeng@bjmu.edu.cn.
Peking University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.

Indexed as

Hepatitis BHepatitis B, ChronicLiver NeoplasmsHepatitis B AntigensHepatitis B VaccinesHepatitis B virusHumansHepatitis B AntigensHepatitis B VaccinesB-cell receptorChronic viral infectionHepatitis B virusHigh-throughput sequencingImmune repertoireT-cell receptor

Identifiers

PMID34321844
PMCPMC8291018
OpenAlexW3186596970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.