Evidence map›Paper›PMID 34321704›Full record

ArticleJournal of the American Statistical Association2021

Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration.

Yingda Jiang, Chi-Yang Chiu, Qi Yan, Wei Chen, Michael B Gorin, Yvette P Conley, M'Hamed Lajmi Lakhal-Chaieb, Richard J Cook, Christopher I Amos, Alexander F Wilson and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Statistical Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. High-Dimensional Gene-Environment Interaction Analysis.Annual review of statistics and its application · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Yingda JiangDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Chi-Yang ChiuDivision of Biostatistics, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN.
Qi YanDivision of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh at The University of Pittsburgh, Pittsburgh, PA.
Wei ChenDivision of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh at The University of Pittsburgh, Pittsburgh, PA.
Michael B GorinDepartment of Ophthalmology, David Geffen School of Medicine, UCLA Stein Eye Institute, Los Angeles, CA.
Yvette P ConleyDepartment of Health Promotion and Development, University of Pittsburgh, Pittsburgh, PA.
M'Hamed Lajmi Lakhal-ChaiebDepartment de Mathematiques et de Statistique, Universite Laval, Quebec, QC, Canada.
Richard J CookDepartment of Statistics and Actuarial Science, Waterloo, ON, Canada.
Christopher I AmosDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Alexander F WilsonComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD.
Joan E Bailey-WilsonComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD.
Francis J McMahonHuman Genetics Branch and Genetic Basis of Mood and Anxiety Disorders Section, National Institute of Mental Health, NIH, Bethesda, MD.
Ana I VazquezDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI.
Ao YuanDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Washington, DC.
Xiaogang ZhongDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Washington, DC.
Momiao XiongHuman Genetics Center, University of Texas, Houston, TX.
Daniel E WeeksDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Ruzong FanComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD.
University of Pittsburgh · USGeorgetown University · USNational Human Genome Research Institute · USBaylor College of Medicine · USMichigan State University · USNational Institute of Mental Health · USUniversité Laval · CAUniversity of Tennessee Health Science Center · USUniversity of Waterloo · CA

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5M
Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7M
The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, andP50AR060772 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2012 to 2021
$12.8M
GENETICS OF AGE-RELATED MACULOPATHYR01EY009859 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GORIN, MICHAEL B · 1993 to 2011
$11.5M
Precision approaches to refining TP53-associated cancer riskR01CA242218 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI AMOS, CHRISTOPHER I., GARBER, JUDY E. · 2019 to 2023
$8.5M
Development of statistical genetics methodologyZIAHG000153 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$5.0M
Coordinating Center: Molecular and Cellular Findings of Screen-Detected LesionsU01CA196386 · NCI · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2015 to 2020
$4.1M
Sequencing Familial Lung CancerU01CA243483 · NCI · BAYLOR COLLEGE OF MEDICINE · PI AMOS, CHRISTOPHER I., PINNEY, SUSAN MENGEL · 2020 to 2022
$2.0M
Statistical methods for population and family-based whole-genome sequence dataR01HG007358 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, WEI · 2014 to 2018
$1.7M
Statistical Tools for Whole-Genome Prediction of Complex Traits and DiseasesR01GM101219 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LOS CAMPOS, GUSTAVO · 2012 to 2017
$1.6M
Statistical Methods for Association Analysis of Complex TraitsZIAHD008918 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI FAN, RUZONG · 2011 to 2016
$1.1M
Intramural NIH HHS Z01 HG000153Intramural NIH HHS ZIA HD008918NCI NIH HHS R01 CA242218NCI NIH HHS U01 CA196386NCI NIH HHS U01 CA243483NCI NIH HHS U19 CA203654NEI NIH HHS R01 EY009859NEI NIH HHS R01 EY024226NHGRI NIH HHS R01 HG007358NIAMS NIH HHS P50 AR060772NIEHS NIH HHS P30 ES006096NIGMS NIH HHS R01 GM099992NIGMS NIH HHS R01 GM101219
6 · The paper itself

Abstract

Genetics plays a role in age-related macular degeneration (AMD), a common cause of blindness in the elderly. There is a need for powerful methods for carrying out region-based association tests between a dichotomous trait like AMD and genetic variants on family data. Here, we apply our new generalized functional linear mixed models (GFLMM) developed to test for gene-based association in a set of AMD families. Using common and rare variants, we observe significant association with two known AMD genes:

Indexed as

Age-related macular degenerationAssociation studyComplex diseasesExtended pedigreeGeneralized functional linear mixed modelsRare variants

Identifiers

PMID34321704
PMCPMC8315575
OpenAlexW3046145719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.