Evidence map›Paper›PMID 34321665›Full record

ArticleNature2021

Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.

Qi Hu, Maria Victoria Botuyan, Debiao Zhao, Gaofeng Cui, Elie Mer, Georges Mer

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 134 citations in OpenAlex.

  1. Precision Chemistry for Protein Lysine Modification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
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  6. Assessing the Clinical Relevance ofCurrent oncology (Toronto, Ont.) · 2026
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  8. Review
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  17. Review
  18. Saturation genome editing ofmedRxiv : the preprint server for health sciences · 2025
    Article
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qi Hu *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3647-8471
Maria Victoria Botuyan *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6466-7432
Debiao Zhao *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Gaofeng CuiDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Elie MerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-2339-9547
Georges MerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. mer.georges@mayo.edu.ORCID http://orcid.org/0000-0002-1900-1578
Mayo Clinic in Arizona · USMayo Clinic · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Structural Biology of Lysine Methylation in DNA Damage and Checkpoint SignalingR01CA132878 · NCI · MAYO CLINIC ROCHESTER · PI Georges Mer · 2008 to 2026
$4.5M
Structural biology of DNA damage response in chromatinR35GM136262 · NIGMS · MAYO CLINIC ROCHESTER · PI MER, GEORGES · 2020 to 2025
$4.2M
Structural basis of RNF168-mediated ubiquitin signaling at chromosomal DNA breaksR01GM116829 · NIGMS · MAYO CLINIC ROCHESTER · PI MER, GEORGES · 2015 to 2018
$1.3M
NCI NIH HHS R01 CA132878NIGMS NIH HHS R01 GM116829NIGMS NIH HHS R35 GM136262NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

The BRCA1-BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of DNA double-strand breaks by homologous recombination

Indexed as

UbiquitinationBRCA1 ProteinCryoelectron MicroscopyDNA RepairHistonesHomologous RecombinationHumansModels, MolecularMutationNeoplasmsNucleosomesProtein DomainsTumor Suppressor p53-Binding Protein 1Tumor Suppressor ProteinsUbiquitinUbiquitin-Conjugating EnzymesBARD1 protein, humanBRCA1 ProteinHistonesNucleosomesTP53BP1 protein, humanTumor Suppressor p53-Binding Protein 1Tumor Suppressor ProteinsUBE2D3 protein, humanUbiquitinUbiquitin-Conjugating EnzymesUbiquitin-Protein Ligases

Identifiers

PMID34321665
PMCPMC8680157
OpenAlexW3186939347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.