ArticleNature2021
Structural basis of ketamine action on human NMDA receptors.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 112 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Features of biliary tract diseases in ketamine abusers: a systematic review of case reports.Journal of medical case reports · 2024Pooled it
- The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature.Frontiers in neuroscience · 2023Pooled it
- Effects of low-dose esketamine on early quality of recovery following minimally invasive esophagectomy: a multicenter, randomized controlled study.Annals of medicine · 2026Trial
- Precision application of target-controlled infusion of esketamine combined with sufentanil in anesthesia for thoracoscopic surgery and its effect on hemodynamics, postoperative pain, and safety.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Trial
- Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression.Neuropsychiatric disease and treatment · 2025Trial
- Effect of Esketamine-Based Opioid-Sparing Anesthesia Protocol on the Quality of Early Recovery After Urological Surgery: A Randomized Clinical Trial.Drug design, development and therapy · 2025Trial
- Effects of adjunctive esketamine on depression in elderly patients undergoing hip fracture surgery: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Safety and efficacy of low-dose esketamine in laparoscopic cholecystectomy: a prospective, double-blind randomized controlled trial.BMC anesthesiology · 2024Trial
- Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.British journal of anaesthesia · 2023Trial
- Microbial Production of Alternative Proteins for Food Applications: Advances, Industrial Challenges, and Regulatory Status.Comprehensive reviews in food science and food safety · 2026Review
- Structural basis of opioid receptor activation by PCP and ketamine.Nature structural & molecular biology · 2026Article
- Bifunctional Modulation of NMDA and Opioid Receptors in Ketamine Reinforcement and Misuse: Implications for Substance Use Disorder Treatment.Biological psychiatry · 2026Review
- Ketamine persists within neuronal compartments long after systemic clearance.Research square · 2026Article
- Efficacy and Safety of Esketamine in Patients Undergoing Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Effect of ketamine intervention on hemodynamic responses in patients with treatment-resistant depression.Scientific reports · 2026Article
- TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.Science advances · 2026Article
- Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells.Biomedicines · 2026Article
- Article
- Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome.Journal of medicinal chemistry · 2026Article
- De Novo Generation-Based Design of Potential Computational Hits Targeting the GluN1-GluN2A Receptor.Molecules (Basel, Switzerland) · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 1 country.
Youyi Zhang *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-7558-6454
Fei Ye *College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.ORCID http://orcid.org/0000-0003-4119-3219
Tongtong Zhang *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-2414-8048
Shiyun LvInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-8779-9430
Liping ZhouUniversity of Chinese Academy of Sciences, Beijing, China.
Daohai DuDrug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-6623-7778
He LinCriminal Investigation Technology Department, The Third Research Institute of Ministry of Public Security, Shanghai, China.
Fei GuoDrug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Cheng LuoUniversity of Chinese Academy of Sciences, Beijing, China. cluo@simm.ac.cn.ORCID http://orcid.org/0000-0003-3864-8382
Shujia ZhuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. shujiazhu@ion.ac.cn.ORCID http://orcid.org/0000-0001-8358-2859
Chinese Academy of Sciences · CNCenter for Excellence in Brain Science and Intelligence Technology · CNMinistry of Public Security of the People's Republic of China · CNShanghai Institute of Materia Medica · CNZhejiang Sci-Tech University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ketamine is a non-competitive channel blocker of N-methyl-D-aspartate (NMDA) receptors
Indexed as
Cryoelectron MicroscopyAntidepressive AgentsAsparagineBinding SitesGlutamic AcidGlycineHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsKetamineLeucineMolecular Dynamics SimulationNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateAntidepressive AgentsAsparagineGlutamic AcidGlycineGprin1 protein, mouseKetamineLeucineNerve Tissue ProteinsNR2B NMDA receptorReceptors, N-Methyl-D-Aspartate
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.