ArticleScientific reports2021
The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
- Relapse in alcohol dependence is characterized by disrupted modular brain network organization.European archives of psychiatry and clinical neuroscience · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Association ofFrontiers in psychiatry · 2026Article
- Global organisation of structural covariance networks derived from parcellated cortical surface area in atypical populations.bioRxiv : the preprint server for biology · 2025Article
- Reconfiguration of functional brain hierarchy in schizophrenia.Translational psychiatry · 2025Article
- A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.Noro psikiyatri arsivi · 2025Review
- Both k-core percolation and directed graph analysis revealed succession and transition of voxels' spatiotemporal progress on dynamic correlation resting-state fMRI.Frontiers in human neuroscience · 2025Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network.Network neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Network biomarkers in recovered psychosis patients who discontinued antipsychotics.Molecular psychiatry · 2023Article
- Neural substrates of verbal memory impairment in schizophrenia: A multimodal connectomics study.Human brain mapping · 2023Article
- Exploring the role of hub and network dysfunction in brain connectomes of schizophrenia using functional magnetic resonance imaging.Frontiers in psychiatry · 2023Article
- Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients.Frontiers in psychiatry · 2022Article
- Constructing graphs from genetic encodings.Scientific reports · 2021Article
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7 authors.
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Abstract
Network neuroscience shed some light on the functional and structural modifications occurring to the brain associated with the phenomenology of schizophrenia. In particular, resting-state functional networks have helped our understanding of the illness by highlighting the global and local alterations within the cerebral organization. We investigated the robustness of the brain functional architecture in 44 medicated schizophrenic patients and 40 healthy comparators through an advanced network analysis of resting-state functional magnetic resonance imaging data. The networks in patients showed more resistance to disconnection than in healthy controls, with an evident discrepancy between the two groups in the node degree distribution computed along a percolation process. Despite a substantial similarity of the basal functional organization between the two groups, the expected hierarchy of healthy brains' modular organization is crumbled in schizophrenia, showing a peculiar arrangement of the functional connections, characterized by several topologically equivalent backbones. Thus, the manifold nature of the functional organization's basal scheme, together with its altered hierarchical modularity, may be crucial in the pathogenesis of schizophrenia. This result fits the disconnection hypothesis that describes schizophrenia as a brain disorder characterized by an abnormal functional integration among brain regions.
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