ArticleNature communications2021
Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- An experimental study on the effect of symptom expectations on mental fatigue and motivation in people with primary biliary cholangitis.Scientific reports · 2025Trial
- Noninvasive Brain Stimulation over the Frontopolar Cortex Promotes Willingness to Exert Cognitive Effort in a Foraging-Like Sequential Choice Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Neural and computational mechanisms of effort under the pressure of a deadline.Nature communications · 2026Article
- Physical and cognitive contributions to fatigue perception: The interplay between local muscle fatigue and sensory prediction error.iScience · 2026Article
- Environmental uncertainty shapes human effort learning.PLoS biology · 2026Article
- Computational signatures of exertion and rest underlie moment-to-moment dynamics of subjective perceptions of effort and fatigue.Cognitive, affective & behavioral neuroscience · 2026Article
- Computational underpinnings of cognitive effortful performance in short timescales.Cognitive, affective & behavioral neuroscience · 2026Article
- Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.Cognitive, affective & behavioral neuroscience · 2026Review
- The cognitive and motor determinants of the perception of effort.Cognitive, affective & behavioral neuroscience · 2026Article
- Temporal dynamics of effort discounting: The roles of cognitive load and depression.Cognitive, affective & behavioral neuroscience · 2026Article
- Relationship Between Food Healthiness, Price Fairness, and Loyalty with Moderating Roles of Temperature, Personalization, and Eco-Friendly Packaging at Subway.Foods (Basel, Switzerland) · 2026Article
- Neural substrates underlying the expectation of rewards resulting from effortful exertion.bioRxiv : the preprint server for biology · 2026Article
- Dopamine Boosts Motivation for Prosocial Effort in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Day-to-day fluctuations in cognitive precision predict the domain-general intention-behavior gap.Science advances · 2026Article
- How visual and proprioceptive feedback mediate the effect of monetary incentive on motor precision.Attention, perception & psychophysics · 2025Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- "If You Haven't Slept a Lot (…) You Don't Want to Go Out for a Run, You Don't Want to Ride a Bike, You Just Kind of Sit and You Just (…) Do Nothing"-Perceptions of 24-Hour Movement Behaviours Among Adolescents Living with Type 1 Diabetes.International journal of environmental research and public health · 2025Article
- Clinical Decision-Making and Use of Clinical Decision Support When Clinicians are Fatigued in an Emergency Department: A Qualitative Study.Applied clinical informatics · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
From a gym workout, to deciding whether to persevere at work, many activities require us to persist in deciding that rewards are 'worth the effort' even as we become fatigued. However, studies examining effort-based decisions typically assume that the willingness to work is static. Here, we use computational modelling on two effort-based tasks, one behavioural and one during fMRI. We show that two hidden states of fatigue fluctuate on a moment-to-moment basis on different timescales but both reduce the willingness to exert effort for reward. The value of one state increases after effort but is 'recoverable' by rests, whereas a second 'unrecoverable' state gradually increases with work. The BOLD response in separate medial and lateral frontal sub-regions covaried with these states when making effort-based decisions, while a distinct fronto-striatal system integrated fatigue with value. These results provide a computational framework for understanding the brain mechanisms of persistence and momentary fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.