Evidence map›Paper›PMID 34321298›Full record

ArticleBMJ open2021

Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries.

Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Lévy, Amy Hai Yan Chan, Manju Chandran, Ching-Lung Cheung and 28 more

Abstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Association of frailty trajectories with osteoporosis and hip fracture in an older female population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Observational
  5. Article
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  7. Management preferences for hip fracture care in Latin America.OTA international : the open access journal of orthopaedic trauma · 2026
    Article
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  10. [Ipsilateral femoral neck fracture after fixation of intertrochanteric fracture by InterTAN intramedullary nail: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
  11. Recruitment and Retention Strategies in Clinical Trials for Hip Fractures: A Cross-Sectional Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025
    Article
  12. Denosumab and clinical outcomes among men with osteoporosis: a retrospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Chor-Wing SingDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong SAR.ORCID 0000-0002-2180-3676
Tzu-Chieh LinCenter for Observational Research, Amgen Inc, Thousand Oaks, California, USA.
Sharon BartholomewCentre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, Ontario, Canada.
J Simon BellCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Corina BennettCenter for Observational Research, Amgen Inc, Thousand Oaks, California, USA.
Kebede BeyeneSchool of Pharmacy, The University of Auckland, Auckland, New Zealand.
Pauline Bosco-LévyBordeaux PharmacoEpi, University of Bordeaux, Bordeaux, France.
Amy Hai Yan ChanSchool of Pharmacy, The University of Auckland, Auckland, New Zealand.
Manju ChandranOsteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital, Singapore.
Ching-Lung CheungDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong SAR.
Caroline Y DoyonCentre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, Ontario, Canada.
Cécile Droz-PerroteauBordeaux PharmacoEpi, University of Bordeaux, Bordeaux, France.
Ganga GanesanMinistry of Health Singapore, Singapore.
Sirpa HartikainenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Jenni IlomakiCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Han Eol JeongSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Douglas P KielHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Kiyoshi KubotaNPO Drug Safety Research Unit Japan, Tokyo, Japan.
Edward Chia-Cheng LaiSchool of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.
Jeff LangeCenter for Observational Research, Amgen Inc, Thousand Oaks, California, USA.
E Michael LewieckiUniversity of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Jiannong LiuChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Kenneth K C ManResearch Department of Practice and Policy, University College London School of Pharmacy, London, UK.ORCID 0000-0001-8645-1942
Mirhelen Mendes de AbreuRheumatology Service, Internal Medicine Department, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-2264-0442
Nicolas MooreBordeaux PharmacoEpi, University of Bordeaux, Bordeaux, France.
James O'KellyCenter for Observational Research, Amgen Inc, Thousand Oaks, California, USA.
Nobuhiro OobaSchool of Pharmacy, The Nihon University, Chiba, Japan.
Alma B PedersenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Daniel Prieto-AlhambraNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, Oxfordshire, UK.ORCID 0000-0002-3950-6346
Ju-Young ShinSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID 0000-0002-2791-1037
Henrik T SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Kelvin Bryan TanMinistry of Health Singapore, Singapore.
Anna-Maija TolppanenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Katia M C VerhammeDepartment of Medical Informatics, Erasmus Medical Center, Rotterdam, Netherlands.ORCID 0000-0001-8162-4904
Grace Hsin-Min WangSchool of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.
Sawaeng WatcharathanakijFaculty of Pharmaceutical Sciences, Ubon Ratchathani University, Mueang Si Khai, Ubon Ratchathani, Thailand.
Hongxin ZhaoShanghai Synyi Medical Technology Co Ltd, Shanghai, China.ORCID 0000-0001-7906-2797
Ian C K WongDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong SAR wongick@hku.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence of hip fracture in people aged 50 years and older. Longitudinal and cross-geographical comparisons of health data can provide insights on aetiology, risk factors, and healthcare practices. However, systematic reviews of studies that use different methods and study periods do not permit direct comparison across geographical regions. Thus, the objective of this study is to investigate global secular trends in hip fracture incidence, mortality and use of postfracture pharmacological treatment across Asia, Oceania, North and South America, and Western and Northern Europe using a unified methodology applied to health records. METHODS AND ANALYSIS: This retrospective cohort study will use a common protocol and an analytical common data model approach to examine incidence of hip fracture across population-based databases in different geographical regions and healthcare settings. The study period will be from 2005 to 2018 subject to data availability in study sites. Patients aged 50 years and older and hospitalised due to hip fracture during the study period will be included. The primary outcome will be expressed as the annual incidence of hip fracture. Secondary outcomes will be the pharmacological treatment rate and mortality within 12 months following initial hip fracture by year. For the primary outcome, crude and standardised incidence of hip fracture will be reported. Linear regression will be used to test for time trends in the annual incidence. For secondary outcomes, the crude mortality and standardised mortality incidence will be reported. ETHICS AND DISSEMINATION: Each participating site will follow the relevant local ethics and regulatory frameworks for study approval. The results of the study will be submitted for peer-reviewed scientific publications and presented at scientific conferences.

Indexed as

Hip FracturesAgedAsiaEuropeHumansIncidenceMiddle AgedRetrospective StudiesSouth Americacalcium & bonediabetes & endocrinologyepidemiologypublic health

Identifiers

PMID34321298
PMCPMC8319985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.