Evidence map›Paper›PMID 34321240›Full record

ArticleCancer research2021

Mutant

Liat Goldberg, Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J Zhu, Robert L Walker, Rachel Pierce, Daxesh P Patel, Kristopher W Krausz, Frank J Gonzalez and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Liat Goldberg *Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Vijay Negi *Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Yang Jo ChungGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Masahiro OnozawaGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Yuelin J ZhuGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Robert L WalkerGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Rachel PierceGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Daxesh P PatelLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.ORCID 0000-0002-7990-2140
Margaret A GoodellDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.ORCID 0000-0003-1111-2932
Benjamin A T RodriguezDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Paul S MeltzerGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Peter D AplanGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. aplanp@mail.nih.gov.
National Cancer Institute · USBaylor College of Medicine · USMassachusetts Department of Public Health · US

Funding

Cancer Genomics Technology DevelopmentZIABC011091 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MELTZER, PAUL S. · 2009 to 2025
$16.9M
Collaborative Pathways that Lead to LeukemiaZIABC010982 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.7M
Activation of Proto-Oncogenes by Chromosomal TranslocationZIASC010378 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.4M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZIABC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.2M
Activation of Proto-Oncogenes--Chromosomal TranslocationZ01SC010378 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER D · 2001 to 2008
$1.5M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZ01BC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2008 to 2008
$344k
Intramural NIH HHS Z01 BC010983Intramural NIH HHS Z01 SC010378Intramural NIH HHS ZIA BC010982Intramural NIH HHS ZIA SC010378
6 · The paper itself

Abstract

Mutations in the isocitrate dehydrogenase 1 (

Indexed as

MutationAnimalsBiomarkers, TumorCell DifferentiationCell Line, TumorComputational BiologyDisease Models, AnimalDisease SusceptibilityDNA MethylationGene Expression ProfilingHeterograftsHomeodomain ProteinsHumansImmunophenotypingIsocitrate DehydrogenaseMiceBiomarkers, TumorHomeodomain ProteinsIDH2 protein, humanIsocitrate DehydrogenaseNuclear Pore Complex ProteinsNUP98-HOXA13 fusion protein, humanOncogene Proteins, Fusion

Identifiers

PMID34321240
PMCPMC8487989
OpenAlexW3186779738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.