Evidence map›Paper›PMID 34321228›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells.

Stephen Man, James E Redman, Deborah L Cross, David K Cole, Ilona Can, Bethan Davies, Shaikh Shimaz Hashimdeen, Reiss Reid, Sian Llewellyn-Lacey, Kelly L Miners and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Characterization of Synthetic Peptides by Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  4. Modified influenza M1NPJ vaccines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Stephen ManDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom; ManS@cf.ac.uk.ORCID 0000-0001-9103-1686
James E RedmanSchool of Chemistry, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0001-5492-2869
Deborah L CrossDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
David K ColeDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Ilona CanDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-4252-4959
Bethan DaviesDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Shaikh Shimaz HashimdeenDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Reiss ReidDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0003-2565-3158
Sian Llewellyn-LaceyDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Kelly L MinersDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Kristin LadellDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Anya LissinaFaculty of Health Sciences, University of Bristol, Bristol, United Kingdom.
Paul E BrownThe Zeeman Institute, University of Warwick, Coventry, United Kingdom; and.ORCID 0000-0002-8764-4583
Linda WooldridgeFaculty of Health Sciences, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-6213-347X
David A PriceDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0001-9416-2737
Pierre J RizkallahDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-9290-0369
Cardiff University · GBInstitute of Infection and Immunity · CAUniversity of Bristol · GBUniversity of Wales Institute Cardiff · SGUniversity of Warwick · GB

Funding

Wellcome Trust 100326
6 · The paper itself

Abstract

The human CD8

Indexed as

Amino Acid SequenceAntigen PresentationCD8-Positive T-LymphocytesCells, CulturedEpitopes, T-LymphocyteHumansLigandsLymphocyte ActivationPeptide FragmentsPeptide LibraryPeptidesEpitopes, T-LymphocyteLigandsPeptide FragmentsPeptide LibraryPeptides

Identifiers

PMID34321228
PMCPMC7615501
OpenAlexW3184371136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.