Evidence map›Paper›PMID 34321211›Full record

ArticleScience advances2021

Regulation of telomere homeostasis and genomic stability in cancer by

Ji Hoon Lee, Juyeong Hong, Zhao Zhang, Bárbara de la Peña Avalos, Cecilia J Proietti, Agustina Roldán Deamicis, Pablo Guzmán G, Hung-Ming Lam, Jose Garcia, Martine P Roudier and 15 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

  1. The Role of NMedComm · 2026
    Review
  2. Review
  3. Review
  4. NNature cell biology · 2026
    Article
  5. Article
  6. Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  7. Article
  8. Ensartinib in a primary pulmonaryFrontiers in medicine · 2025
    Article
  9. N6-methyladenosine RNA landscape in the aged mouse hearts.Frontiers in cardiovascular medicine · 2025
    Article
  10. Review
  11. Review
  12. Recruitment of the mGenome biology · 2024
    Article
  13. Functions and mechanisms of RNA mInternational journal of oncology · 2024
    Review
  14. Progression of mCell death discovery · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 4 countries.

Ji Hoon LeeDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0002-7488-3999
Juyeong HongDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-6383-8474
Zhao ZhangDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0002-3679-8945
Bárbara de la Peña AvalosDepartment of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-9796-8015
Cecilia J ProiettiLaboratory of Molecular Mechanisms of Carcinogenesis and Molecular Endocrinology, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires C1428ADN, Argentina.ORCID http://orcid.org/0000-0001-5875-4540
Agustina Roldán DeamicisLaboratory of Molecular Mechanisms of Carcinogenesis and Molecular Endocrinology, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires C1428ADN, Argentina.ORCID http://orcid.org/0000-0002-9129-7246
Pablo Guzmán GDepartamento de Anatomía Patológica (BIOREN), Universidad de La Frontera, Temuco Casilla 54-D, Chile.ORCID http://orcid.org/0000-0001-5741-3584
Hung-Ming LamDepartment of Urology, University of Washington, Seattle, WA 98195, USA.
Jose GarciaDepartment of Urology, University of Washington, Seattle, WA 98195, USA.
Martine P RoudierDepartment of Urology, University of Washington, Seattle, WA 98195, USA.
Anthony E SiskDepartment of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0001-7262-3985
Richard De La RosaDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-9611-1060
Kevin VuDepartment of Medical Education, Joe R. and Teresa Lozano Long School of Medicine, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0002-1288-147X
Mei YangDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Yiji LiaoDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Jessica ScheirerDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0003-3882-7604
Douglas PechacekDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0002-5279-9972
Pooja YadavDepartment of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Manjeet K RaoDepartment of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-7573-2677
Siyuan ZhengGreehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Teresa L Johnson-PaisDepartment of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-7580-1206
Robin J LeachMays Cancer Center, UT Health San Antonio MD Anderson, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0002-3201-5579
Patricia V ElizaldeLaboratory of Molecular Mechanisms of Carcinogenesis and Molecular Endocrinology, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires C1428ADN, Argentina.ORCID http://orcid.org/0000-0002-5923-9898
Eloïse DrayDepartment of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID http://orcid.org/0000-0001-6793-9838
Kexin XuDepartment of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. xuk3@uthscsa.edu.ORCID http://orcid.org/0000-0002-2850-2083
The University of Texas Health Science Center at San Antonio · USExperimental Medicine and Biology Institute · ARThe University of Texas MD Anderson Cancer Center · USUniversity of Washington · USHospital Clínico Universitario Lozano Blesa · ESUniversidad de La Frontera · CLUniversity of California, Los Angeles · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

The role of RNA methylation on

Identifiers

PMID34321211
PMCPMC8318370
OpenAlexW3184271221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.