ArticleScience advances2021
Model-based aversive learning in humans is supported by preferential task state reactivation.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Transdiagnostic mental health symptom dimensions predict use of flexible model-based inference in complex environments.Translational psychiatry · 2026Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Striatal arbitration between choice strategies guides few-shot adaptation.Nature communications · 2025Article
- Context changes retrieval of prospective outcomes during decision deliberation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Reactivation strength during cued recall is modulated by graph distance within cognitive maps.eLife · 2024Article
- Heuristics in risky decision-making relate to preferential representation of information.Nature communications · 2024Article
- Interactive cognitive maps support flexible behavior under threat.Cell reports · 2023Article
- Identifying Transdiagnostic Mechanisms in Mental Health Using Computational Factor Modeling.Biological psychiatry · 2023Review
- Differential replay of reward and punishment paths predicts approach and avoidance.Nature neuroscience · 2023Article
- Distinct replay signatures for prospective decision-making and memory preservation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Large-scale neural network computations and multivariate representations during approach-avoidance conflict decision-making.NeuroImage · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Decoding cognition from spontaneous neural activity.Nature reviews. Neuroscience · 2022Review
- Relationship Between Replay-Associated Ripples and HippocampalSchizophrenia bulletin open · 2022Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Harm avoidance is critical for survival, yet little is known regarding the neural mechanisms supporting avoidance in the absence of trial-and-error experience. Flexible avoidance may be supported by a mental model (i.e., model-based), a process for which neural reactivation and sequential replay have emerged as candidate mechanisms. During an aversive learning task, combined with magnetoencephalography, we show prospective and retrospective reactivation during planning and learning, respectively, coupled to evidence for sequential replay. Specifically, when individuals plan in an aversive context, we find preferential reactivation of subsequently chosen goal states. Stronger reactivation is associated with greater hippocampal theta power. At outcome receipt, unchosen goal states are reactivated regardless of outcome valence. Replay of paths leading to goal states was modulated by outcome valence, with aversive outcomes associated with stronger reverse replay than safe outcomes. Our findings are suggestive of avoidance involving simulation of unexperienced states through hippocampally mediated reactivation and replay.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.