ArticleScience advances2021
Characterizing dedifferentiation of thyroid cancer by integrated analysis.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 5 of them syntheses that pooled it.
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118citing papers in PubMed, 5 pooled it
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Who cites it
118 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Rationale for Testing TP53 Mutations in Thyroid Cancer-Original Data and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Radioactive iodine therapy for thyroid cancer coexisting with Hashimoto's thyroiditis: a systematic review and meta-analysis.The British journal of radiology · 2024Pooled it
- Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.Virchows Archiv : an international journal of pathology · 2024Pooled it
- Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7.Cell death & disease · 2023Pooled it
- Primary Versus Secondary Anaplastic Thyroid Carcinoma: Perspectives from Multi-institutional and Population-Level Data.Endocrine pathology · 2021Pooled it
- Synergistic role of molecular imaging and genomics in thyroid cancer management: from diagnosis to personalized treatment.Journal of translational medicine · 2026Review
- Single-Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling.Cancer medicine · 2026Article
- Anaplastic thyroid cancer: genomic landscape, molecular drivers and novel therapeutics.Nature reviews. Endocrinology · 2026Review
- Spatial and single-nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers.Molecular oncology · 2026Article
- Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma.European thyroid journal · 2026Review
- Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression.Chinese medical journal · 2026Article
- CCR7-PERK-CREB3L1 signaling mediates tumor-associated macrophages-derived SPP1 promotion of oral squamous cell carcinoma.Communications biology · 2026Article
- Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer.Molecular cancer · 2026Article
- Single cell multiomics unravel the transcription networks controlling the different EMT tumor states.Nature communications · 2026Article
- PRECISE: A Prognostic Thyrocyte-Derived Gene Signature for Papillary Thyroid Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Deciphering functional intra-tumoral heterogeneity in BRAFOncogene · 2026Article
- ZFP148 is a transcriptional repressor of cytolytic effector CD8Nature immunology · 2026Article
- Gene expression profile, and role of baicalein in the inhibition of thyroid cancer.Translational cancer research · 2026Article
- Dual-targeting CD133/PD-L1 CAR-T plus αPD-1 overcomes immunosuppressive microenvironment and enhanced by radiation pre-conditioning.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Cancer Stemness and Dedifferentiation in Anaplastic Thyroid Carcinoma: Insights into a Multigenic, Microenvironmental Network and the Role of CD44.Biomedicines · 2026Review
58 more citing papers are in PubMed but not listed here.
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Authors and funding
31 authors.
Han LuoDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-9674-0139
Xuyang XiaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0003-4230-7265
Gyeong Dae KimSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-9288-6341
Yang LiuDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-1339-0760
Zhinan XueState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
Lingyun ZhangDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yang ShuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-8304-1531
Tian YangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0003-4742-2190
Yan ChenState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
Shouyue ZhangState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0001-5780-5190
Haining ChenDepartment of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0003-0104-8498
Weihan ZhangDepartment of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-9498-8245
Ruicen LiHealth Promotion Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huairong TangHealth Promotion Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Birong DongNational Clinical Research Center for Geriatrics, Chengdu, Sichuan, China.
Xianghui FuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0001-9808-3892
Wei ChengState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
Wei ZhangDepartment of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li YangState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-7880-2113
Yong PengState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-1181-3467
Lunzhi DaiState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-3003-8910
Hongbo HuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-8177-7641
Yong JiangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Changyang GongState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
Yiguo HuDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-3973-2140
Jingqiang ZhuDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-0794-9169
Zhihui LiDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Carlos CaulinDepartment of Otolaryngology-Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-5059-0016
Tao WeiDepartment of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. xuheng81916@scu.edu.cn jihwan.park@gist.ac.kr surgeonwei@163.com.ORCID http://orcid.org/0000-0002-7070-5992
Jihwan ParkSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea. xuheng81916@scu.edu.cn jihwan.park@gist.ac.kr surgeonwei@163.com.ORCID http://orcid.org/0000-0002-5728-912X
Heng XuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. xuheng81916@scu.edu.cn jihwan.park@gist.ac.kr surgeonwei@163.com.ORCID http://orcid.org/0000-0002-7748-2621
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of
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