Evidence map›Paper›PMID 34321149›Full record

ArticleOncology research2022

miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer.

Hui Li, Han-Han Li, Qian Chen, Yu-Yang Wang, Chang-Chang Fan, Yuan-Yuan Duan, You Huang, Hui-Min Zhang, Jia-Peng Li, Xiao-Yu Zhang and 5 more

Abstract read
In one paragraph

Article in Oncology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Decoding the Epigenome of Breast Cancer.International journal of molecular sciences · 2025
    Review
  5. Review
  6. International journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hui LiDepartment of Hematology and Nephrology, Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyHubeiP.R. China.
Han-Han LiNanjing Vazyme Biotech Co. Ltd.NanjingP.R. China.
Qian ChenCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Yu-Yang WangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Chang-Chang FanCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Yuan-Yuan DuanCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
You HuangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Hui-Min ZhangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Jia-Peng LiCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Xiao-Yu ZhangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Yuan XiangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Chao-Jiang GuCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Li WangSchool of Resource and Environmental Engineering, Wuhan University of Science and TechnologyHubeiP.R. China.
Xing-Hua LiaoCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.
Tong-Cun ZhangCollege of Life Sciences and Health, Wuhan University of Science and TechnologyHubeiP.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved

Indexed as

Breast NeoplasmsMicroRNAs3' Untranslated RegionsCell Line, TumorCell MovementCell ProliferationDNA (Cytosine-5-)-Methyltransferase 1FemaleGene Expression Regulation, NeoplasticHumans3' Untranslated RegionsDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanMicroRNAsMIRN142 microRNA, human

Identifiers

PMID34321149
PMCPMC8790130

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.