Observational studyCritical care (London, England)2021
Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS.
Observational study in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2022Pooled it
- High-Flow Nasal Oxygen for Severe Hypoxemia: Oxygenation Response and Outcome in Patients with COVID-19.American journal of respiratory and critical care medicine · 2022Pooled it
- Comparison of PEEP titration methods to improve respiratory system compliance in acute respiratory distress syndrome: a randomized controlled study.Critical care science · 2026Trial
- Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry.Journal of anesthesia, analgesia and critical care · 2026Article
- Is Mechanical Power the Trojan Horse? Emphasizing the Role of Driving Pressure.Medicina (Kaunas, Lithuania) · 2025Article
- Mechanical power is an early predictor of mortality in mechanically ventilated patients with COVID-19.BMJ open respiratory research · 2025Article
- A Comparative Analysis of Early Ventilator Mechanics in COVID-19 vs. Non-COVID-19 ARDS: A Single-Center ED-Based Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients.Annals of intensive care · 2025Article
- Postoperative atrial arrhythmias after bilateral lung transplantation with intraoperative V-A extracorporeal membrane oxygenation: a single-center experience.Frontiers in transplantation · 2025Article
- Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation.BMJ open respiratory research · 2024Article
- Predictive value of invasive mechanical ventilation parameters for mortality in COVID-19 related ARDS: a retrospective cohort study.Scientific reports · 2024Observational
- Early association between respiratory mechanics and radiological changes in mechanically ventilated critically ill patients with COVID-19.Internal and emergency medicine · 2024Article
- Development and evaluation of a mechanical ventilator-sharing system.Frontiers in medicine · 2024Article
- Comprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort study.Respiratory research · 2023Article
- Driving pressure and adjunctive therapies in pulmonary sequelae of COVID-19 patients under invasive ventilation.Intensive care medicine · 2023Article
- A Retrospective Analysis of the Effects of Time on Compliance and Driving Pressures in ARDS.Respiratory care · 2023Article
- Outcomes of COVID-19 Patients with Severe Hypoxemic Acute Respiratory Failure: Non-Invasive Ventilation vs. Straight Intubation-A Propensity Score-Matched Multicenter Cohort Study.Journal of clinical medicine · 2022Article
- Expert opinion document: "Electrical impedance tomography: applications from the intensive care unit and beyond".Journal of anesthesia, analgesia and critical care · 2022Review
- Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench.Frontiers in physiology · 2022Review
- COVID-19 ICU mortality prediction: a machine learning approach using SuperLearner algorithm.Journal of anesthesia, analgesia and critical care · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPathophysiological features of coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) were indicated to be somewhat different from those described in nonCOVID-19 ARDS, because of relatively preserved compliance of the respiratory system despite marked hypoxemia. We aim ascertaining whether respiratory system static compliance (Crs), driving pressure (DP), and tidal volume normalized for ideal body weight (VT/kg IBW) at the 1st day of controlled mechanical ventilation are associated with intensive care unit (ICU) mortality in COVID-19 ARDS.
methodsObservational multicenter cohort study. All consecutive COVID-19 adult patients admitted to 25 ICUs belonging to the COVID-19 VENETO ICU network (February 28th-April 28th, 2020), who received controlled mechanical ventilation, were screened. Only patients fulfilling ARDS criteria and with complete records of Crs, DP and VT/kg IBW within the 1st day of controlled mechanical ventilation were included. Crs, DP and VT/kg IBW were collected in sedated, paralyzed and supine patients.
resultsA total of 704 COVID-19 patients were screened and 241 enrolled. Seventy-one patients (29%) died in ICU. The logistic regression analysis showed that: (1) Crs was not linearly associated with ICU mortality (p value for nonlinearity = 0.01), with a greater risk of death for values < 48 ml/cmH
conclusionsCrs < 48 ml/cmH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.