Evidence map›Paper›PMID 34320994›Full record

ArticleJournal of nanobiotechnology2021

Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(-/-) mice.

Qi Wang, Yong Wang, Siwen Liu, Xuan Sha, Xiaoxi Song, Yue Dai, Mingming Zhao, Lulu Cai, Kai Xu, Jingjing Li

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  7. Article
  8. How Advanced Is Nanomedicine for Atherosclerosis?International journal of nanomedicine · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Multiscale physics-basedFrontiers in drug delivery · 2024
    Review
  13. Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qi Wang *School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Yong Wang *School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Siwen LiuSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Xuan ShaSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Xiaoxi SongSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Yue DaiSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Mingming ZhaoSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Lulu CaiSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China.
Kai XuSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China. xkpaper@163.com.
Jingjing LiSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, 221006, China. qingchao0124@163.com.ORCID http://orcid.org/0000-0002-6149-3350
Xuzhou Medical College · CN

Funding

Jiangsu Provincial Medical Youth Talent QNRC2016776National Natural Science Foundation of China 81771904Natural Science Foundation of Jiangsu Province BK20170054Six one project of Jiangsu Province LGY2018083Six Talent Peaks Project in Jiangsu Province WSN-112
6 · The paper itself

Abstract

backgroundRupture of atherosclerotic plaque can cause acute malignant heart and cerebrovascular events, such as acute coronary heart disease, stroke and so on, which seriously threaten the safety of human life and property. Therefore, the early diagnosis and inhibition of atherosclerotic plaque progress still be a vital task.

resultsIn this study, we presented the development of composite mesoporous silica nanoparticle (Ru(bpy)

conclusionsThe designed CMSN@SRT@Anti with excellent biocompatibility, high-performance and superior atherosclerosis-targeting ability has great potential for accurate identification and targeted therapy of atherosclerotic diseases.

Indexed as

AnimalsApolipoproteins EAtherosclerosisCD36 AntigensDrug LiberationFluorescenceHeterocyclic Compounds, 4 or More RingsLipoproteins, LDLMacrophagesMiceMice, KnockoutNIH 3T3 CellsOptical ImagingPlaque, AmyloidPlaque, AtheroscleroticPrecision MedicineApoe protein, mouseApolipoproteins ECD36 AntigensHeterocyclic Compounds, 4 or More RingsLipoproteins, LDLoxidized low density lipoproteinSilicon DioxideSRT1720AtherosclerosisFluorescence imagingMacrophageTheranostic nanomedicines

Identifiers

PMID34320994
PMCPMC8317354
OpenAlexW3165356988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.