SynthesisBMC cardiovascular disorders2021
Dose approach matter? A meta-analysis of outcomes following transfemoral versus transapical transcatheter aortic valve replacement.
Synthesis in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Same-Day Discharge After Transcatheter Aortic Valve Implantation: Who, When, and How?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Review
- Minimally Invasive Cardiac Surgery: A State-of-the-Art Review.Journal of clinical medicine · 2026Review
- Comparison of TAVR and SAVR in elderly patients with pure native aortic regurgitation: outcomes and midterm results.Cardiovascular diagnosis and therapy · 2025Article
- Outcomes of transcatheter aortic valve implantation for native aortic valve regurgitation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Exploring Optimal Strategies for Surgical Access in Transcatheter Aortic Valve Implantation.Journal of clinical medicine · 2024Review
- Trans-femoral versus trans-carotid access for transcatheter aortic valve replacement: an updated systematic review and meta-analysis.Future science OA · 2024Review
- Transapical Delivery of a Sapien Valve for Transcatheter Aortic Valve Replacement in an 11-Year-Old Patient with Truncus Arteriosus.Pediatric cardiology · 2023Article
- Risk Factors, Management, and Avoidance of Conduction System Disease after Transcatheter Aortic Valve Replacement.Journal of clinical medicine · 2023Review
- Cerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation.Journal of Zhejiang University. Science. B · 2023Article
- Temporal changes of patient characteristics over 12 years in a single-center transcatheter aortic valve implantation cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- A case report of transcatheter repair of severe functional mitral regurgitation in cardiac amyloidosis.European heart journal. Case reports · 2023Article
- Predicting permanent pacemaker implantation following transcatheter aortic valve replacement: A contemporary meta-analysis of 981,168 patients.Heart rhythm O2 · 2022Article
- Comparing Clinical and Hemodynamic Parameters between the Two Aortic Valve Replacement in Patients with Severe Aortic Stenosis.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter aortic valve replacement (TAVR) has gained increasing acceptance for patients with aortic disease. Both transfemoral (TF-TAVR) and transapical (TA-TAVR) approach were widely adopted while their performances are limited to a few studies with controversial results. This meta-analysis aimed to compare the mortality and morbidity of complications between TF- versus TA-TAVR based on the latest data.
methodsElectronic databases were searched until April 2021. RCTs and observational studies comparing the outcomes between TF-TAVR versus TA-TAVR patients were included. Heterogeneity assumption was assessed by an I
resultsThe meta-analysis included 1 RCT and 20 observational studies, enrolling 19,520 patients (TF-TAVR, n = 11,986 and TA-TAVR, n = 7,534). Compared with TA-TAVR, TF-TAVR patients showed significantly lower rate of postoperative in-hospital death (OR = 0.67, 95% CI 0.59-0.77, P < 0.001) and 1-year death (OR = 0.53, 95% CI 0.41-0.69, P < 0.001). Incidence of major bleeding and acute kidney injury were lower and length of hospital stay was shorter, whereas those of permanent pacemaker and major vascular complication were higher in TF-TAVR patients. There were no significant differences between TF-TAVR versus TA-TAVR for stroke and mid-term mortality.
conclusionsThere were fewer early deaths in patients with transfemoral approach, whereas the number of mid-term deaths and stroke was not significantly different between two approaches. TF-TAVR was associated with lower risk of bleeding, acute kidney injury as well as shorter in-hospital stay, but higher incidence of vascular complication and permanent pacemaker implantation.
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