ArticleMolecular biology and evolution2021
Two Reference-Quality Sea Snake Genomes Reveal Their Divergent Evolution of Adaptive Traits and Venom Systems.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 46 citations in OpenAlex.
- Evolution of chromosomes and nuclear architectures of amniotes.Nature communications · 2025Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- A Chromosome-level Genome Assembly of the Western Nose-Horned Viper (Vipera ammodytes ammodytes).Genome biology and evolution · 2025Article
- Genomic signatures of subterranean lifestyle and ecological adaptation in Myospalax.BMC biology · 2025Article
- A Segregating Structural Variant Defines Novel Venom Phenotypes in the Eastern Diamondback Rattlesnake.Molecular biology and evolution · 2025Article
- Sex Chromosome Turnovers and Stability in Snakes.Molecular biology and evolution · 2025Article
- A first look at the genome structure of hexaploid "Mitcham" peppermint (Mentha × piperita L.).G3 (Bethesda, Md.) · 2024Article
- VenomCap: An exon-capture probe set for the targeted sequencing of snake venom genes.Molecular ecology resources · 2024Article
- Where the "ruber" Meets the Road: Using the Genome of the Red Diamond Rattlesnake to Unravel the Evolutionary Processes Driving Venom Evolution.Genome biology and evolution · 2024Article
- Chromosome-level genome assembly and annotation of the Rhabdophis nuchalis (Hubei keelback).Scientific data · 2024Article
- Dynamic Expansions and Retinal Expression of Spectrally Distinct Short-Wavelength Opsin Genes in Sea Snakes.Genome biology and evolution · 2024Article
- Genomic features for adaptation and evolutionary dynamics of four major Asian domestic carps.Science China. Life sciences · 2024Article
- Review
- Convergent genomic signatures associated with vertebrate viviparity.BMC biology · 2024Article
- Accounting for diverse transposable element landscapes is key to developing and evaluating accurate de novo annotation strategies.Genome biology · 2024Article
- ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages.GigaScience · 2024Article
- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- Pangenome of water caltrop reveals structural variations and asymmetric subgenome divergence after allopolyploidization.Horticulture research · 2023Article
- Exploring objective feature sets in constructing the evolution relationship of animal genome sequences.BMC genomics · 2023Article
- Considering admixture when producing draft genomes: an example in North American ratsnakes (Pantherophis alleghaniensis/Pantherophis obsoletus).G3 (Bethesda, Md.) · 2023Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
True sea snakes (Hydrophiini) are among the last and most successful clades of vertebrates that show secondary marine adaptation, exhibiting diverse phenotypic traits and lethal venom systems. To better understand their evolution, we generated the first chromosome-level genomes of two representative Hydrophiini snakes, Hydrophis cyanocinctus and H. curtus. Through comparative genomics we identified a great expansion of the underwater olfaction-related V2R gene family, consisting of more than 1,000 copies in both snakes. A series of chromosome rearrangements and genomic structural variations were recognized, including large inversions longer than 30 megabase (Mb) on sex chromosomes which potentially affect key functional genes associated with differentiated phenotypes between the two species. By integrating multiomics we found a significant loss of the major weapon for elapid predation, three-finger toxin genes, which displayed a dosage effect in H. curtus. These genetic changes may imply mechanisms that drove the divergent evolution of adaptive traits including prey preferences between the two closely related snakes. Our reference-quality sea snake genomes also enrich the repositories for addressing important issues on the evolution of marine tetrapods, and provide a resource for discovering marine-derived biological products.
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