Evidence map›Paper›PMID 34320379›Full record

ArticleJournal of structural biology2021

Role of a high centrality residue in protein dynamics and thermal stability.

Vitor Medeiros Almeida, Apala Chaudhuri, Marcus Vinicius Cangussu Cardoso, Bruno Yasui Matsuyama, Gláucio Monteiro Ferreira, Gustavo Henrique Goulart Trossini, Roberto Kopke Salinas, J Patrick Loria, Sandro Roberto Marana

Abstract read
In one paragraph

Article in Journal of structural biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Temperature induces a shift from insulin dihexamer to hexamer in collective dynamics.Protein science : a publication of the Protein Society · 2025
    Article
  3. Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of the influenza A virus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Allostery in Protein Tyrosine Phosphatases is Enabled by Divergent Dynamics.Journal of chemical information and modeling · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vitor Medeiros AlmeidaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
Apala ChaudhuriDepartament of Chemistry, Yale University, New Haven, CT, United States.
Marcus Vinicius Cangussu CardosoDepartamento de Química, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, MG, Brazil.
Bruno Yasui MatsuyamaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
Gláucio Monteiro FerreiraSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Gustavo Henrique Goulart TrossiniSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Roberto Kopke SalinasDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
J Patrick LoriaDepartament of Chemistry, Yale University, New Haven, CT, United States; Departament of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Sandro Roberto MaranaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: srmarana@iq.usp.br.

Funding

Computational and Biochemical Studies of Temperature Effects on Allostery in the Imidazole Glycerol Phosphate Synthase (IGPS) from T. maritimaR01GM106121 · NIGMS · YALE UNIVERSITY · PI BATISTA, VICTOR S, LORIA, JOSEPH P · 2014 to 2021
$2.3M
NIGMS NIH HHS R01 GM106121
6 · The paper itself

Abstract

Centralities determined from Residue Interaction Networks (RIN) in proteins have been used to predict aspects of their structure and dynamics. Here, we correlate the Eigenvector Centrality (E

Indexed as

ProteinsThermotoga maritimaModels, MolecularProtein ConformationProteinsCentralityMolecular dynamicsNMRProtein stabilityResidue interaction network

Identifiers

PMID34320379
PMCPMC10859912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.