ArticleImmunity2021
Resident cardiac macrophages mediate adaptive myocardial remodeling.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
20.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023Pooled it
- A metabolic-epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition.Nature cardiovascular research · 2026Article
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Heart Failure with Reduced versus Preserved Ejection Fraction: Molecular Mechanisms, Immunologic Pathways, Current Therapies, and Future Directions.Archives of internal medicine research · 2026Article
- Fate-mapping infiltrating monocytes following experimental myocardial infarction reveals differentiation trajectories in the infarcted heart.The Journal of clinical investigation · 2026Article
- Gut microbiota-activated PLCγ2 monocytes drive atrial fibrillation.Nature communications · 2026Article
- Cardiomyocyte-macrophage cross-talk reduces doxorubicin cardiotoxicity by polarizing macrophages via EV miR-142-3p/135a-5p.iScience · 2026Article
- Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.Development (Cambridge, England) · 2026Article
- Mitochondria Clearance Enables Macrophage-Driven Maturation of iPSC-Derived Cardiomyocyte Metabolism.Cellular and molecular bioengineering · 2026Article
- Review
- Breast cancer susceptibility gene 2 upregulation alleviated cardiac hypertrophy in angiotensin II-treated mice.Biochemistry and biophysics reports · 2026Article
- Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4Genes & diseases · 2026Article
- Single-Nucleus RNA Sequencing Reveals SPP1Journal of cardiovascular development and disease · 2026Article
- Assessing Venous Congestion in Heart Failure: A Review of Splanchnic, Cardiac, and Pulmonary Ultrasound: Part 2: Contrast-Enhanced Ultrasound and Shear Wave.Journal of clinical medicine · 2026Review
- Macrophage surface protein Mac-2 mediates inflammatory and stromal stress pathways in doxorubicin-induced cardiac injury.Cardio-oncology (London, England) · 2026Article
- M2 macrophage exosomes reverse heart failure post-myocardial infarction by suppressing type 1 interferon signaling in myeloid cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Article
- DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function.Science immunology · 2026Article
- Immunometabolic regulation of cardiac macrophages in heart failure with preserved ejection fraction.Frontiers in immunology · 2026Review
- Identification of MTURN as a trained immunity-related biomarker for heart failureFrontiers in immunology · 2026Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 2 institutions in 2 countries.
Nicole R WongDepartmental of Medicine, Washington University School of Medicine.
Jay MohanDepartmental of Medicine, Washington University School of Medicine.
Benjamin J KopeckyDepartmental of Medicine, Washington University School of Medicine.
Shuchi GuoDepartmental of Medicine, Washington University School of Medicine.
Lixia DuDepartment of Anesthesiology, Washington University School of Medicine.
Jamison LeidDepartmental of Medicine, Washington University School of Medicine.
Guoshuai FengDepartmental of Medicine, Washington University School of Medicine.
Inessa LokshinaDepartmental of Medicine, Washington University School of Medicine.
Oleksandr DmytrenkoDepartmental of Medicine, Washington University School of Medicine.
Hannah LuehmannDepartment of Radiology, Washington University School of Medicine.
Geetika BajpaiDepartmental of Medicine, Washington University School of Medicine.
Laura EwaldDepartmental of Medicine, Washington University School of Medicine.
Lauren BellDepartmental of Medicine, Washington University School of Medicine.
Nikhil PatelDepartmental of Genetics, Washington University School of Medicine.
Andrea BredemeyerDepartmental of Medicine, Washington University School of Medicine.
Carla J WeinheimerDepartmental of Medicine, Washington University School of Medicine.
Jessica M NigroDepartmental of Medicine, Washington University School of Medicine.
Attila KovacsDepartmental of Medicine, Washington University School of Medicine.
Sachio MorimotoDepartment of Physical Therapy, International University of Health and Welfare, Japan.
Peter O BayguinovDepartment of Biochemistry, Washington University School of Medicine.
Max R FisherDepartment of Biochemistry, Washington University School of Medicine.
W Tom StumpDepartment of Biochemistry, Washington University School of Medicine.
Michael GreenbergDepartment of Biochemistry, Washington University School of Medicine.
James A J FitzpatrickWashington University Center for Cellular Imaging, Washington University School of Medicine; Departments of Neuroscience, Cell Biology & Physiology, and Biomedical Engineering, Washington University School of Medicine.
Slava EpelmanToronto General Hospital Research Institute, University Health Network.
Daniel KreiselDepartment of Pathology and Immunology, Washington University School of Medicine; Department of Surgery, Washington University School of Medicine.
Rajan SahDepartmental of Medicine, Washington University School of Medicine.
Yongjian LiuDepartment of Radiology, Washington University School of Medicine.
Hongzhen HuDepartment of Anesthesiology, Washington University School of Medicine.
Kory J LavineDepartmental of Medicine, Washington University School of Medicine; Department of Pathology and Immunology, Washington University School of Medicine; Department of Developmental Biology, Washington University School of Medicine. Electronic address: klavine@wustl.edu.
International University of Health and Welfare · JPToronto General Hospital · CA
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MThe Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Daniel Kreisel · 2015 to 2026
$19.4MTraining/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7MTHE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9MTargeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1MPediatric Cardiovascular and Pulmonary Research Training Program.T32HL125241 · NHLBI · WASHINGTON UNIVERSITY · PI Juliane Bubeck Wardenburg, Kory J. Lavine · 2015 to 2026
$4.1MMolecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2021 to 2025
$3.7MTARGETING THE TRANSIENT RECEPTOR POTENTIAL CHANNELS TO IMPROVE BOWEL DYSFUNCTIONR01DK103901 · NIDDK · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2015 to 2023
$3.4MRegulation of cardiac power output in health and diseaseR01HL141086 · NHLBI · WASHINGTON UNIVERSITY · PI GREENBERG, MICHAEL J · 2018 to 2022
$2.7MDeciphering the Piezo2-Merkel cell signaling mechanisms in itchR01AR077183 · NIAMS · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2020 to 2024
$2.6MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MMECHANISMS OF TRPV4-MEDIATED NEUROPATHIC PAINR01AA027065 · NIAAA · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2018 to 2022
$2.5MBLRD VA I01 BX002730NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL131908NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL141086NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R35 HL145212NHLBI NIH HHS T32 HL125241NIAAA NIH HHS R01 AA027065NIAID NIH HHS P01 AI116501NIAID NIH HHS R21 AI148877NIAMS NIH HHS R01 AR077183NIBIB NIH HHS P41 EB025815NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK103901NIH HHS S10 OD021694NIH HHS S10 OD028597
Abstract
Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine Receptor 2 positive (CCR2
Indexed as
AnimalsCardiomyopathy, DilatedHumansMacrophage ActivationMacrophagesMiceMice, Inbred C57BLMice, Mutant StrainsMutationMyocardiumTroponin TVentricular RemodelingTNNT2 protein, humanTroponin Tangiogenesiscardiac remodelingC-C chemokine receptor 2CCR2dilated cardiomyopathyheart failuremacrophagestransient receptor potentialvanilloid 4TRPV4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.