Evidence map›Paper›PMID 34320185›Full record

ArticleThe Journal of infectious diseases2022

Effectiveness of Human Papillomavirus (HPV) Vaccination Against Penile HPV Infection in Men Who Have Sex With Men and Transgender Women.

Rachel L Winer, John Lin, Troy D Querec, Elizabeth R Unger, Joshua E Stern, Jessica M Rudd, Matthew R Golden, Fred Swanson, Lauri E Markowitz, Elissa Meites

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Immune Responses to Human Papillomavirus After Infection and Vaccination.Current topics in microbiology and immunology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Factors Related to HPV Vaccination Intention among MSM in China: A Bayesian Network Model.International journal of environmental research and public health · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rachel L WinerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
John LinDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Troy D QuerecDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Elizabeth R UngerDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Joshua E SternDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Jessica M RuddDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Matthew R GoldenCenter for AIDS & STD, University of Washington, Seattle, Washington, USA.
Fred SwansonGay City Health Project, Seattle, Washington, USA.
Lauri E MarkowitzDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Elissa MeitesDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-0077-2591
Centers for Disease Control and Prevention · USUniversity of Washington · USGay City Health Project · US

Funding

Health Promotion and Disease Prevention Research CenterU48DP005013 · DP · UNIVERSITY OF WASHINGTON · PI HANNON, MARGARET A · 2014 to 2018
$13.3M
ACL HHS U48DP005013Intramural CDC HHS CC999999NCCDPHP CDC HHS U48 DP005013
6 · The paper itself

Abstract

backgroundIn the United States, human papillomavirus (HPV) vaccination has been recommended since 2011 for boys aged 11-12 years, with catch-up vaccination recommended through age 26 years for previously unvaccinated men who have sex with men (MSM).

methodsDuring 2016-2018, a cross-sectional study enrolled MSM and transgender women aged 18-26 years in Seattle, Washington. Participants submitted self-collected penile swab specimens for HPV genotyping. HPV vaccination history was self-reported. We compared HPV prevalence among vaccinated participants with that in participants with no or unknown vaccination history, using log-binomial regression to estimate adjusted prevalence ratios and confidence intervals.

resultsAmong 687 participants, 348 (50.7%) self-reported ever receiving ≥1 HPV vaccine dose; the median age at first HPV vaccination was 21 years, and the median age at first sex, 17 years. Overall, the prevalence of penile quadrivalent HPV vaccine (4vHPV)-type HPV was similar in vaccinated participants (12.1%) and participants with no or unknown vaccination (15.6%) (adjusted prevalence ratio, 0.69 [95% confidence interval, .47-1.01]). However, the prevalence was significantly lower in participants vaccinated at age ≤18 years than in those with no of unknown vaccination (0.15 [.04-.62]), corresponding to a vaccine effectiveness of 85% against 4vHPV-type HPV.

conclusionsResults suggest that HPV vaccination is effective in preventing penile HPV infections in young MSM when administered at age ≤18 years.

Indexed as

AlphapapillomavirusPapillomavirus InfectionsPapillomavirus VaccinesSexual and Gender MinoritiesTransgender PersonsAdolescentCross-Sectional StudiesFemaleHomosexuality, MaleHumansMalePapillomaviridaeUnited StatesVaccinationPapillomavirus Vaccinespapillomavirus infectionspapillomavirus vaccinessexual and gender minoritiesvaccination

Identifiers

PMID34320185
PMCPMC8842819
OpenAlexW3183316797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.